Results 121 to 130 of about 2,125,818 (314)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2011 This work reports an amperometric method for phosphate analysis based on the use of a surface modified glassy carbon electrode (GC). In one configuration of the electrode the surface is modified with ammonium heptamolybdate incorporated in chitosan ...
Singh, P. +5 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Jhamarkotra phosphate ore processing plant
, 2009 : Low grade phosphate ore of Jhamarkotra that analyzes 16.5% P~2~O~5~ is upgraded to 34% P~2~O~5~ by a two stage flotation process after size reducing the ore to 90% passing through 200mesh using conventional equipment such as jaw and cone crushers ...
Sekhar Dmr, C.L Jain
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Global dataset on phosphate mining and beneficiation
<p>The dataset covers worldwide production of phosphate rock (PR) at the level of phosphate mining and beneficiation complex. The objective is to gather complex-specific data on the P content of mined and beneficiated resource and on the recovery ...
Anna Shchiptsova
core +2 more sources
Sodium Benzoate as Promoter in the Soap Flotation of Phosphate Minerals
, 2011 In the present study we show that sodium benzoate substantially improves the efficiency of Soap LDO collector in the flotation of phosphate minerals. ...
Mihir DM +2 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source