Results 121 to 130 of about 2,299,534 (313)

Efficient biocatalytic synthesis of D-tagatose 1,6-diphosphate by LacC-catalysed phosphorylation of D-tagatose 6-phosphate

, 2019
D-tagatose 1,6-diphosphate is an important metabolite which can be formed via the classical tagatose 6-phosphate pathway or via the tagatose 1-phosphate pathway discovered more recently.
Roland Meier (65695), Thorsten Eggert (308299), Roland Wohlgemuth (2715493), Bernhard Schoenenberger (2661361), Markus Obkircher (2025316), Stefanie Kind (6869024)   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Phosphate-assisted phytoremediation of arsenic by Brassica napus and Brassica juncea: Morphological and physiological response

, 2017
In this study, we examined the potential role of phosphate (P; 0, 50, 100 mg kg−1) on growth, gas exchange attributes, and photosynthetic pigments of Brassica napus and Brassica juncea under arsenic (As) stress (0, 25, 50, 75 mg kg−1) in a pot experiment.
Behzad Murtaza (3635857), Muhammad Bilal Shakoor (3635860), Hailong Wang (21678), Yong Sik Ok (1697134), Nabeel Khan Niazi (2154526), Irshad Bibi (2154535), Muhammad Shahid (536390), Muhammad Tariq Javed (3635863), Safdar Bashir (1898899), Ayesha Fatimah (3635854), Zulfiqar Ahmad Saqib (3635866)   +10 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Acoustic emission characteristics and damage constitutive model of fractured sandstone under uniaxial compression

Scientific Reports
To investigate the statistical laws of acoustic emission energy (AEE) avalanche dynamics of sandstone under varying fracture lengths and dip angles, as well as to determine the relationship between acoustic emission (AE) parameters and damage variables ...
Qiang Liu, Chao Pan, Lin Yan, Xuguang Wang, Shujian Li, Juncai Cao   +5 more
doaj   +1 more source

Phosphate overload via the type III Na-dependent Pi transporter represses aortic wall elastic fiber formation

Fujita Medical Journal
Objectives: Phosphate (Pi) induces differentiation of arterial smooth muscle cells to the osteoblastic phenotype by inducing the type III Na-dependent Pi transporter Pit-1/solute carrier family member 1.
Yasumasa Yoshino, Tomoka Hasegawa, Shukei Sugita, Eisuke Tomatsu, Naoya Murao, Izumi Hiratsuka, Sahoko Sekiguchi-Ueda, Megumi Shibata, Takeo Matsumoto, Norio Amizuka, Yusuke Seino, Takeshi Takayanagi, Yoshihisa Sugimura, Atsushi Suzuki   +13 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Phosphorus availability as a function of its time of contact with different soils

Revista Brasileira de Engenharia Agrícola e Ambiental
Phosphorus (P) availability is related to soil sorption capacity and is relevant to planning P fertilization and evaluating its residual effect. The aim of this work was to evaluate the P availability to maize plants after different incubation times of ...
Hemmannuella C. Santos, Fábio H. T. de Oliveira, Adailson P. de Souza, Ignácio H. Salcedo, Valério D. M. Silva   +4 more
doaj   +1 more source

The determination of phosphate in seawater by reverse flow injection spectrophotometry

Reviews in Analytical Chemistry, 2012
A simple, sensitive, accurate and portable reverse flow injection (rFIA) spectrophotometric method is proposed for the on-line determination of trace phosphate in seawater.
Li Hui, Zhang Xinshen, Yu Lingyun, Wang Li, Chen Shujuan   +4 more
doaj   +1 more source