Results 51 to 60 of about 1,967,106 (296)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Research on ecological restoration and green reclamation technology of goaf in phosphorus mines

Frontiers in Environmental Science
The subsidiary of Yunnan Phosphate Group Co., Ltd., Kunyang Phosphate Mine’s mining area is the subject of study. The mining of open-pit phosphate mines has caused significant damage to the ecological environment.
Di Hou, Mengchao Xu, Mengchao Xu, Mengchao Xu, Menglai Wang, Xiaoshuang Li, Xiaoshuang Li, Shujian Li, Jiawen Wang, Mengzhen Cao   +9 more
doaj   +1 more source

Continuous enzyme-coupled assay of phosphate- or pyrophosphate-releasing enzymes

BioTechniques, 2012
A coupled enzyme assay able to monitor the kinetics of reactions catalyzed by phosphate- or pyrophosphate-releasing enzymes is presented here.
Antonio S. Guillén Suárez, Alessandra Stefan, Silvia Lemma, Emanuele Conte, Alejandro Hochkoeppler   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dicyclohexylammonium O,O’-Diphenyl Phosphate, [(C6H11)2NH2][(C6H5O)2P(O)(O)]: Spectroscopic Study, Crystal Structure, and Hirshfeld Surface Analysis

Molbank, 2019
The title salt, [(C6H11)2NH2][(C6H5O)2P(O)(O)], crystallizes in the chiral space group P212121, composed of achiral cation and anion components. The strong charge-assisted N–H…O hydrogen bonds build a linear assembly along the a axis, including a non ...
Samira Nazari Moghaddam, Akbar Raissi Shabari, Fahimeh Sabbaghi, Mehrdad Pourayoubi, Abdul Ajees Abdul Salam   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Modification and validation of cracked zone range under coupled in-situ stress and blasting load

Scientific Reports
Exploring the characteristics of blasting crack propagation under the action of in-situ stress is of great significance for guiding the layout of blast holes on site.
Xingchao TIAN, Tiejun TAO, Lang HUANG
doaj   +1 more source

Influence of Organic Impurities on Fractional Crystallization of NaCl and Na₂SO₄ from High-Salinity Coal Chemical Wastewater: Thermodynamics and Nucleation Kinetics Analysis

Molecules
It is a valid path to realize the zero discharge of coal chemical wastewater by using the fractional crystallization method to recycle the miscellaneous salt in high-salinity wastewater. In this study, the thermodynamics and nucleation kinetics of sodium
Bo Shen, Bo Zhao, Hai Du, Yongsheng Ren, Jianwei Tang, Yong Liu, Quanxian Hua, Baoming Wang   +7 more
doaj   +1 more source

Magnetic Mg-Fe/LDH Intercalated Activated Carbon Composites for Nitrate and Phosphate Removal from Wastewater: Insight into Behavior and Mechanisms [PDF]

, 2020
Omar Alagha, Mohammad Saood Manzar, Mukarram Zubair, İsmail Anil, Nuhu Dalhat Mu’azu, Aleem Qureshi   +5 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source