Results 91 to 100 of about 917,897 (332)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Studi Kemampuan Pati Biji Durian Sebagai Bahan Pengikat Dalam Tablet Ketoprofen Secara Granulasi Basah [PDF]

, 2006
Many type of starch from various plants can be exploited as an alternative for additional materials in tablet formulation. One of the source that have been developed as a pharmaceutical excipient is durian seed starch, which relatively easy to find in
Firli, R. D. (Rosmala), Jufri, M. (Mahdi)   +1 more
core  

The Effect of Moderate Dietary Protein and Phosphate Restriction on Calcium-Phosphate Homeostasis in Healthy Older Cats [PDF]

, 2016
Background Dietary phosphate and protein restriction decreases plasma PTH and FGF‐23 concentrations and improves survival time in azotemic cats, but has not been examined in cats that are not azotemic.
Antoniucci, Backlund, Barber, Barber, Berndt, Brown, Burnett, Dong, Elliott, Ferrari, Finch, Finch, Finch, Freeman, Geddes, Geddes, Greene, Hall, Hoek, Hutchins-Wiese, Isakova, Isakova, Isakova, Jepson, Jepson, Jepson, Jepson, Kamycheva, Kumar, Laflamme, Larsson, Lulich, Marino, Moe, Muntner, Nishida, NRC, Paepe, Parker, Pineda, Reynolds, Ross, Saito, Schulz, Shipov, Sigrist, Spatz, Trivedi, Wakeling, Wakeling, Williams, Zhang   +51 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Molybdenum disulfide mixtures make effective high-vacuum lubricants [PDF]

, 1964
Five different mixtures of molybdenum disulfide are found to be effective bearing lubricants when tested at very low pressures and high ...

core   +1 more source

Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]

, 1987
Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core   +2 more sources

Meal phosphate variability does not support fixed dose phosphate binder schedules for patients treated with peritoneal dialysis: a prospective cohort study

BMC Nephrology, 2015
BackgroundRemoval of phosphate by peritoneal dialysis is insufficient to maintain normal serum phosphate levels such that most patients must take phosphate binders with their meals.
S. Leung, B. McCormick, Jessica Wagner, M. Biyani, S. Lavoie, Rameez Imtiaz, D. Zimmerman   +6 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Phosphate-control adherence in hemodialysis patients: current perspectives

Patient Preference and Adherence, 2018
Ebele M Umeukeje,1–3 Amanda S Mixon,3,4 Kerri L Cavanaugh1–3 1Vanderbilt Center for Kidney Disease, Nashville, TN, USA; 2Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville TN, USA; 3Vanderbilt ...
Umeukeje EM, Mixon AS, Cavanaugh KL
doaj  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source