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The therapeutic potential of novel phosphate binders
Pediatric Nephrology, 2005Hyperphosphatemia and an increased serum calcium-phosphate (CaxP) product are associated with cardiovascular mortality in adult dialysis patients. Target levels for the treatment of elevations in serum phosphorus (P) and the CaxP product have recently been redefined, but are difficult to achieve in clinical practice.
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Aluminum-free oral phosphate binder.
Clinical nephrology, 1986For the purpose of intestinal phosphate binding we have developed aluminum free substances. These substances are natural polymers consisting of heteropolyuronic acid charged with different cations. The in vitro experiments showed an efficacy 2 to 3 times greater than Aludrox. During the clinical application, up to one year, no serious side effects have
H, Schneider +3 more
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[Novel phosphate binders under development].
Clinical calcium, 2009Controlling serum phosphorus levels in patients with chronic kidney disease is crucial. Since hyperphosphatemia is an established risk factor for not only secondary hyperparathyroidism, but also cardiovascular mortality in these patients, the adequate control of serum phosphorus is necessary.
Masahide, Mizobuchi +2 more
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[Phosphate binder up to date].
Clinical calcium, 2007It has become clear that hyperphosphatemia is the major risk factor on the patients' survival undergoing regular renal replacement therapy. One of the mechanism of this impact on survival is ectopic calcification like vascular calcification. The standard therapy for hyperphosphatemia is phosphate removal by renal replacement therapy. However, since the
Takashi, Shigematsu +2 more
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[Management of hyperphosphatemia ; phosphate-binder].
Clinical calcium, 2009Numerous experimental and clinical studies have recently addressed the underlying mechanisms in particular the marked increase in cardiovascular mortality in patients with CKD. Hyperphosphatemia is a major problem in these patients with advanced stage of CKD. Calcium carbonate became the most widely used phosphate binders ; however, increasing evidence
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The reaction of calcium during the formation of metakaolin phosphate geopolymer binder
Cement and Concrete Research, 2022Jean Noel Yankwa Djobo
exaly