Results 51 to 60 of about 582,852 (293)

Lanthanum carbonate - A first line phosphate binder?

, 2007
Hyperphosphatemia is associated with increased morbidity and mortality in dialysis patients. Oral phosphate binders are necessary to control serum phosphate in patients eating a normal diet and undergoing peritoneal dialysis or thrice weekly hemodialysis.
De Freitas, Declan, Donne, Rosemary L., Hutchison, Alastair, Hutchison, Alastair J.   +3 more
core   +1 more source

Impact of vascular calcification on cardiovascular mortality in hemodialysis patients: clinical significance, mechanisms and possible strategies for treatment

Renal Replacement Therapy, 2017
Vascular calcification has now been recognized as a major problem in dialysis patients because of its strong influence on the prognosis. Along with the regulatory failure of calcification-inhibitory system, active phenotypic change of vascular smooth ...
Takayasu Ohtake, Shuzo Kobayashi
doaj   +1 more source

Study of Printing Parameters in Binder Jet Additive Manufacturing of Cobalt Chrome - Tricalcium Phosphate Biocomposite [PDF]

, 2021
Traditional metals such as stainless steel, titanium and cobalt chrome are used in biomedical applications (implants, scaffolds etc.) but suffer from issues such as osseointegration and compatibility with existing bone.
Agarwal, Kuldeep, Ruprecht, John
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effects of Phosphate Binders in Moderate CKD [PDF]

Journal of the American Society of Nephrology, 2012
Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and efficacy in this population are not well understood. Here, we aimed to determine the effects of phosphate binders on parameters of mineral metabolism and vascular calcification among patients with ...
Geoffrey A, Block, David C, Wheeler, Martha S, Persky, Bryan, Kestenbaum, Markus, Ketteler, David M, Spiegel, Matthew A, Allison, John, Asplin, Gerard, Smits, Andrew N, Hoofnagle, Laura, Kooienga, Ravi, Thadhani, Michael, Mannstadt, Myles, Wolf, Glenn M, Chertow   +14 more
openaire   +2 more sources

Improving phosphate-binder therapy as a way forward

, 2004
Aluminium- or calcium-based phosphate-binding agents traditionally have been used to treat hyperphosphataemia in patients with end-stage renal disease. Although these agents effectively lower serum phosphorus levels, they are associated with serious side
Hutchison, Alastair J.
core   +1 more source

Analysis of rheological behaviour of titanium feedstocks formulated with a water-soluble binder system for powder injection moulding [PDF]

, 2014
Binder selection and formulation are critical in powder injection moulding. Binders play a key role in controlling the rheological properties of a feedstock and influence whether the resulting feedstock can be successfully injection moulded, debound and ...
Pickering, Kim L., Thavanayagam, Gnanavinthan, Swan, Janis E., Cao, Peng   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Production of phosphate binder fire-protective coating for steel building constructions [PDF]

, 2012
Brief analysis of means for fire protection of steel building constructions was given, special attention being paid to the advantages of using phosphate binders for protective coatings.
Rumynskaya, E. I., Kuzmenkov, M. I.
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source