Results 41 to 50 of about 23,252 (243)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Choosing Not to Take Phosphate Binders : The Role of Dialysis Patients' Medication Beliefs

open access: yes, 2011
Objective: Patients with end-stage renal disease (ESRD) receiving haemodialysis are at risk of cardiovascular disease and bone disorders related to high levels of serum phosphate (PO(4)).
Hughes, Lyndsay   +5 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Efficacy of non-calcium phosphate binders compared to calcium phosphate binders in the treatment of hyperphosphatemia in stage III-V CKD

open access: yes, 2021
Patients with stages III-V CKD have increased risk for cardiovascular mortality due the correlation between the renal and cardiovascular systems, partially due to hyperphosphatemia.
Schlagel, Scott
core  

Creation of self-hardening aluminum phosphate binders for manufacturing foundry cores

open access: yesAdvances in Industrial and Manufacturing Engineering, 2023
The aims of this publication is to study the physical and chemical conditions of formation of self-hardening aluminum phosphate binders based on orthophosphoric acid and fine-grained aluminum powder, research of its chemical structure and properties of ...
I. Petryk   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Effectiveness and Cost-Efficacy of Phosphate Binders in Hemodialysis

open access: yes, 2011
<i>Objectives:</i> Worldwide, incidence rates of chronic renal insufficiency have clearly increased over the past decade, especially in people of older age.
Sophie Brunner-Ziegler   +3 more
core   +1 more source

Multidisciplinary Perspectives of Current Approaches and Clinical Gaps in the Management of Hyperphosphatemia

open access: yesInternational Journal of Nephrology and Renovascular Disease, 2021
Michel Vallée,1 Jordan Weinstein,2 Marisa Battistella,3 Roxanne Papineau,4 Dianne Moseley,5 Gordon Wong6 1Université de Montréal - Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada; 2Division of Nephrology, St Michael’s Hospital, University of ...
Vallée M   +5 more
doaj  

Comparative analysis of the phosphate-binding effects of sucroferric oxyhydroxide, ferric citrate, and lanthanum carbonate

open access: yesRenal Replacement Therapy, 2017
Background Iron-based phosphate binders are widely used in hemodialysis, to avoid the increased mortality associated with high serum phosphate in dialysis patients.
Takeo Ishii   +2 more
doaj   +1 more source

Evaluation of intestinal phosphate binding to improve the safety profile of oral sodium phosphate bowel cleansing. [PDF]

open access: yesPLoS ONE, 2015
Prior to colonoscopy, bowel cleansing is performed for which frequently oral sodium phosphate (OSP) is used. OSP results in significant hyperphosphatemia and cases of acute kidney injury (AKI) referred to as acute phosphate nephropathy (APN ...
Stef Robijn   +3 more
doaj   +1 more source

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