Results 51 to 60 of about 23,252 (243)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Control of serum phosphate without any phosphate binders in patients treated with nocturnal hemodialysis

, 1998
Control of serum phosphate without any phosphate binders in patients treated with nocturnal hemodialysis. We compared the efficacy and the long-term effects of nocturnal hemodialysis (NHD) versus conventional hemodialysis (CHD) in controlling serum ...
Francoeur, Robert, Hercz, Gavril, Pierratos, Andreas, Uldall, Robert, Ouwendyk, Michaelene, Mucsi, Istvan   +5 more
core   +1 more source

Clinical and economic aspects of sevelamer therapy in end-stage renal disease patients

International Journal of Nephrology and Renovascular Disease, 2014
Shahrzad OssarehDepartment of Medicine, Nephrology Section, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, IranAbstract: Phosphate control is still a great challenge in chronic kidney disease (CKD), and in spite of the great ...
Ossareh S
doaj  

Clinical Evaluation of the Safety, Efficacy and Tolerability of Lanthanum Carbonate in the Management of Hyperphosphatemia in Patients with End-Stage Renal Disease

Therapeutics and Clinical Risk Management, 2020
Valeria Cernaro, Sebastiano Calimeri, Alfredo Laudani, Domenico Santoro Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyCorrespondence: Valeria CernaroUnit of Nephrology and Dialysis,
Cernaro V, Calimeri S, Laudani A, Santoro D   +3 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Preparation and study of thermostable composites based on solid magnesium phosphate and calcium phosphate binders

Журнал Белорусского государственного университета: Химия, 2021
Thermostable composite materials based on solid magnesium phosphate and calcium phosphate, as well as hybrid calcium magnesium phosphate binders have been developed and investigated. Thermal and phase transformations of the phosphate composites have been
Natalia S. Apanasevich, Konstantin N. Lapko, Alexander N. Kudlash, Aliaksei A. Sokal, Yury D. Kliaulin, Konstantin V. Vishnevskii   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Inhibition of Hydrogen Evolution in Aluminium-phosphate Refractory Binders

, 2016
The study deals with the possibilities of inhibition of the reaction of aluminium-phosphate binders with iron scale, which is contained in bauxite. This material is mixed with phosphate binders to form refractories.
Šoukal, František, Ptáček, Petr, Pařízek, Ladislav, Bednárek, Jan, Švec, Jiří   +4 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Phosphate binders

, 2008
The work deals with the preparation and study of polyphosphate composites. Aluminum phosphates provide some unusual properties like high-heat resistance in terms of inorganic binders.
Kalina, Lukáš
core   +1 more source