Results 71 to 80 of about 23,252 (243)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
PLoS ONE, 2017 BackgroundChronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents,
Nigar Sekercioglu +7 more
doaj +1 more source
Drugs in Context, 2017 Background: Calcium-based and non-calcium-based phosphate binders have similar efficacy in the treatment of hyperphosphatemia; however, calcium-based binders may be associated with hypercalcemia, vascular calcification, and adynamic bone disease ...
Rosamund J Wilson, J Brian Copley
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Phosphate Binders in Refractory Application
, 2015 The doctoral thesis is focused on the study, research and development of refractories with phosphate bonding. Primary motivation is preparation of phosphate-based binders that can be applied for non-shaped insulating material fabricated by “in situ ...
Švec, Jiří
core
Oral phosphate binders for the management of serum phosphate levels in dialysis patients
, 2009 Hyperphosphataemia is an inevitable consequence of end stage chronic kidney disease and is present in the majority of dialysis patients. Hyperphosphataemia is statistically associated with increased cardiovascular mortality among dialysis patients ...
Mohammed, Ismail +3 more
core +1 more source
The Key Role of Phosphate on Vascular Calcification
Toxins, 2019 Vascular calcification (VC) is common in dialysis and non-dialysis chronic kidney disease (CKD) patients, even in the early stage of the disease. For this reason, it can be considered a CKD hallmark.
Mario Cozzolino +6 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Investigating Sulphate Binders Replacement for Phosphate Binders in Tundish Plasters
Journal of Advanced Materials in Engineering, 2009 One of the main reasons for the blocking and sticking of the expendable layer in tundish plaster to the permanent layer and the subsequent increase in refractory consumption and associated costs is the use of low-melting phosphate binders.
S.M. Siadati, A. Monshi
doaj