Results 91 to 100 of about 22,921 (213)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Effect of a transtheoretical model-based intervention and motivational interviewing on hyperphosphatemia management via telehealth (TMT program) among hemodialysis patients during the COVID-19 pandemic

Frontiers in Public Health
BackgroundHyperphosphatemia poses a significant risk for cardiovascular diseases and mortality in hemodialysis patients. Non-adherence to phosphate binders and a low-phosphate diet behavior contribute to this issue.
Arrom Thongsunti, Chatchawan Silpakit, Thanapoom Rattananupong, Wonngarm Kittanamongkolchai, Wonngarm Kittanamongkolchai, Wonngarm Kittanamongkolchai, Warangkana Sumethpimolchai, Vitool Lohsoonthorn   +7 more
doaj   +1 more source

Effect of the P/Al Molar Ratio and Heating Rate on the Composi-Tion of Alumino-Phosphate Binders. [PDF]

Materials (Basel), 2022
Tricot G, Hu H, Beaussart A, Fernandes I, Perrot C.   +4 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Development tendencies of moulding and core sands [PDF]

China Foundry, 2011
Further development of the technology for making moulding and core sands will be strictly limited by tough requirements due to protection of the natural environment.
Stanislaw M. Dobosz1, Petr Jelinek, Katarzyna Major-Gabrys   +2 more
doaj  

Effect of Phosphate Binders and a Dietary Iron Supplement on the Pharmacokinetics of a Single Dose of Vadadustat in Healthy Adults. [PDF]

Clin Pharmacol Drug Dev, 2022
Paulson SK, Martinez J, Sawant R, Burke SK, Chavan A.   +4 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

THE EFFECT OF PHOSPHATE BINDERS AND CALCITRIOL ON RENAL OSTEODISTROPHY

Turkish Journal of Nephrology, 2019
Renal osteodistrophy occurs due to the factors such as secondary hyperparathyroidism, active vitamin D deficiency, aluminium retention and heparin used during hemodialysis.
Mahmut YAVUZ, Mustafa GÜLLÜLÜ, Kamil DİLEK, Mustafa YURTKURAN   +3 more
doaj  

Impact of phosphate binders on quality of life in dialysis patients: Results from the prospective Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes study. [PDF]

Nephrology (Carlton), 2022
Colombijn JMT, Vonk S, Cornelis T, Boorsma S, Krekels MME, Abrahams AC, van Jaarsveld BC.   +6 more
europepmc   +1 more source