Results 211 to 220 of about 642,082 (258)
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Phosphate homeostasis and hypophosphatemia
The American Journal of Medicine, 1982The clinical importance of an understanding of phosphate metabolism is derived from the crucial role of this anion in the regulation of many cellular functions. In recent years, a greater appreciation of disorders of phosphate metabolism has been recognized because of more frequent monitoring of serum phosphate concentration as well as the increased ...
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Phosphatonins and the Regulation of Phosphate Homeostasis
Annual Review of Physiology, 2007Inorganic phosphate (Pi) is required for energy metabolism, nucleic acid synthesis, bone mineralization, and cell signaling. The activity of cell-surface sodium-phosphate (Na+-Pi) cotransporters mediates the uptake of Pi from the extracellular environment.
Theresa, Berndt, Rajiv, Kumar
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A phosphate-sensing organelle regulates phosphate and tissue homeostasis
Nature, 2023Inorganic phosphate (Pi) is one of the essential molecules for life. However, little is known about intracellular Pi metabolism and signalling in animal tissues1. Following the observation that chronic Pi starvation causes hyperproliferation in the digestive epithelium of Drosophila melanogaster, we determined that Pi starvation triggers the ...
Chiwei Xu +9 more
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Recent findings in phosphate homeostasis
Current Opinion in Nephrology & Hypertension, 2005We summarize the most recent findings on the proteins that interact with sodium/inorganic phosphate (Na/Pi) cotransporters, the factors that regulate Pi homeostasis and their role in pathology.Studies in animal models and cell lines identified proteins mandatory to correct trafficking of the kidney-specific Na/Pi cotransporter NPT2a and its control by ...
Dominique, Prié +3 more
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Developmental Changes in Phosphate Homeostasis
2020Phosphate is a multivalent ion critical for a variety of physiological functions including bone formation, which occurs rapidly in the developing infant. In order to ensure maximal bone mineralization, young animals must maintain a positive phosphate balance.
Tate, MacDonald +3 more
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FGF23 and disorders of phosphate homeostasis
Cytokine & Growth Factor Reviews, 2005It is well known that fibroblast growth factor (FGF) family members are associated with embryonic development and are critical for basic metabolic functions. This review will focus upon fibroblast growth factor-23 (FGF23) and its roles in disorders associated with phosphate handling.
Xijie, Yu, Kenneth E, White
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Phosphate Homeostasis and Disorders of Phosphate Metabolism
Current Pediatric ReviewsAbstract: Phosphate is indispensable for human life and evolutionary changes over several millions of years have established tightly regulated mechanisms to ensure phosphate homeostasis. In this process, calcium and phosphate metabolism have come to be intricately linked together.
Nandhini Lakshmana Perumal +1 more
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2015
Abstract Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids.
Heini Murer +2 more
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Abstract Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids.
Heini Murer +2 more
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Homeostasis of inorganic phosphate: An introductory review
Calcified Tissue Research, 1975Body phosphorus is to the greatest extent (80–90%) in the bone mineral as calcium phosphate. The rest is in the soft tissues and in the blood. In the latter, it is either in the red cells mostly as esters and phospholipids, or in the plasma as esters, lipids and inorganic phosphate. Only the homeostasis of inorganic phosphate will be considered in this
H, Fleisch, J P, Bonjour, U, Troehler
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Phosphate and Acid-Base Homeostasis
1980Both because of its properties as a buffer and its function as a major intracellular anion, phosphate plays a pivotal role in the maintenance of acid-base homeostasis. This review is concerned with the impact of phosphate on three interrelated aspects of acid-base physiology and pathophysiology.
N A, Kurtzman, J A, Arruda
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