Results 131 to 140 of about 125,468 (314)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Surface properties of some calcium phosphates [PDF]

, 1951
RESP ...
Rickson, J. B.
core  

Correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with chronic disease of the kidneys untreated with replacement renal therapy

Терапевтический архив, 2009
Aim. To characterize correlations between the levels of vitamin D, parathormone, calcium, blood phosphates in patients with different stages of chronic disease of the kidney (CDK) given no therapy replacing renal function (TRRF).
Aleksey Vladimirovich Smirnov, Mikhail Mikhaylovich Volkov, Ol'ga Vladimirovna Galkina, Aleksandr Anatol'evich Zhloba, Vladimir Leonidovich Emanuel', A V Smirnov, M M Volkov, O V Galkina, A A Zhloba, V L Emanel   +9 more
doaj  

The war anthropogenic impact on the conditions of the Desna river surface waters

Людина і довкілля: Проблеми неоекології
Purpose. To provide a comprehensive environmental assessment of the condition of the surface waters of the Desna River in order to identify the main anthropogenic factors of impact, in particular the consequences of the war. Methods.
L. A. Horoshkovа, O. I. Menshov, Y. D. Korniichuk, A. O. Soloviova   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Phosphate retention by soil in relation to waste disposal [PDF]

, 1979
The disposal of large amounts of domestic sewage water and liquid manure, both containing dissolved phosphates, is often problematic. Discharge of these into (shallow and standing) surface waters is highly undesirable, as phosphate is considered to be ...
Beek, J.
core  

Bernard Pelletier

Revista CENIC Ciencias Químicas, 2017
Bernard Pelletier (1761-1797) a pharmacist and physician, devoted his short life to the application of chemistry to practical problems of industry and national activity in France.
Jaime Wisniak
doaj  

Ecological assessment of surface water conditions of the Danube river

Вісник Харківського національного університету імені В.Н. Каразіна: Серія Екологія
Purpose. To provide a comprehensive environmental assessment and forecasting of the condition of surface waters of the Danube River within the Ukrainian section (Reni – Izmail – Vylkove), with a focus on the dynamics of key hydrochemical indicators over ...
L. A. Horoshkovа, O. I. Menshov, Y. D. Korniichuk, S. V. Horoshkov, I. V. Ryshykov   +4 more
doaj   +1 more source