Results 111 to 120 of about 125,203 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Copper-substituted tricalcium phosphates

, 2020
© 2016, Pleiades Publishing, Ltd.Copper-substituted tricalcium phosphates (CuTCP) with different copper contents were developed using precipitation of copper-containing amorphous calcium phosphates (ACP) from salt solutions followed by heat treatment ...
Davydova G., Petrakova N., Fadeeva I., Filippov Y., Fomin A., Barinov S., Gafurov M., Gabbasov B., Antonova O., Orlinsky S., Izotov V., Savintseva I., Akhmetov L.   +12 more
core  

A review of Pachyvaranus crassispondylus Arambourg, 1952, a pachyostotic marine squamate from the latest Cretaceous phosphates of Morocco and Syria

, 2011
International audienceThe discovery of new specimens of Pachyvaranus crassispondylus Arambourg, 1952 from the Maastrichtian phosphates of Morocco and Syria enables us to (1) redescribe in detail this poorly known varanoid lizard, (2) provide a more ...
Houssaye, Alexandra, Amalik, Mohamed, Rage, Jean-Claude, Bardet, Nathalie, Pereda Suberbiola, Xabier, BOUYA, BAÂDI, Amaghzaz, Mbarek   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Polylactic Acid - Calcium Phosphates Composites

Calcium phosphates (CaP) have excellent biomaterial properties due to their similarity to the inorganic component of the bone matrix. However, CaP clinical application is restricted due to their inherent brittleness and poor shepe ability.
Sokolova, Marina, Ločs, Jānis, Zālīte, Vita, Bērziņa-Cimdiņa, Līga   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Calcium phosphates for biomedical applications

, 2017
The history of calcium phosphates in the medicine field starts in 1769 when the first evidence of its existence in the bone tissue is discovered. Since then, the interest for calcium phosphates has increased among the scientific community.
Maria Canillas, Pilar Pena, Antonio H. de Aza, Miguel A. Rodríguez   +3 more
core   +1 more source

Efficient phosphate removal from water using ductile cast iron waste: a response surface methodology approach

Frontiers in Chemistry
Water scarcity is a critical issue worldwide. This study explores a novel method for addressing this issue by using ductile cast iron (DCI) solid waste as an adsorbent for phosphate ions, supporting the circular economy in water remediation.
Mai Hassan Roushdy, Nada Amr Elkhashab, Ahmed Ibrahim Osman, Dalia Amer Ali   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source