Results 101 to 110 of about 125,468 (314)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Antimicrobial and Antioxidant Properties of Phosphates Used in Meat Products [PDF]

open access: yes, 2017
Phosphates are widely used as food additives in meat products to increase the water-holding capacity, reduce the cooking loss and improve the textural properties.
Azim Şimşek, Birol Kılıç
core   +2 more sources

Phosphate level predicts mortality in acute kidney injury patients undergoing continuous kidney replacement therapy and has a U-shaped association with mortality in patients with high disease severity: a multicenter retrospective study [PDF]

open access: yesKidney Research and Clinical Practice
Background This study investigated the association between serum phosphate level and mortality in acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT) and evaluated whether this association differed according to ...
Young Hwan Lee   +15 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Fourier Transform Infrared Spectra of Technologically Modified Calcium Phosphates [PDF]

open access: yes
Calcium phosphate powders were synthesized by wet-chemical precipitation method using CaCO3 and H3PO4 as starting materials. Influence of technological parameters on chemical composition of as-prepared and thermal treated calcium phosphate samples were ...
Borodajenko, Natālija   +4 more
core  

Les phosphates de Gafsa [PDF]

open access: yes, 1957
Brunet Roger. Les phosphates de Gafsa. In: L'information géographique, volume 21, n°4, 1957. pp.
Brunet, Roger
core   +1 more source

Phosphorus and Fluorine - The Union for Bioregulators [PDF]

open access: yesKemija u Industriji, 2007
The review demonstrates the very high efficiency and usefulness of the fluorine-phosphorus combination in order to synthesize organic molecules for purposes of modern life science.
Romanenko, V., Kukhar, V.
doaj  

Comprehensive effect of Al2O3 content and binary basicity on the enrichment mechanism of phosphates in quenched steelmaking slags

open access: yes工程科学学报, 2016
A comprehensive effect of Al2O3 content and binary basicity B on the enrichment behavior of phosphates in rapidly quenched CaO-SiO2-FeO-P2O5-Fe2O3-Al2O3 steelmaking slags was investigated through thermodynamic calculations and experimental determination.
LI Jin-yan   +3 more
doaj   +1 more source

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