Results 91 to 100 of about 5,041,800 (310)

Antiviral nucleoside diphosphate diglycerides: improved synthesis and facilitated purification.

Journal of Lipid Research, 1992
Cytidine diphosphate diglyceride and its analogs have previously been synthesized by condensing phosphatidic acid with the monophosphomorpholidates of the various nucleosides. Yields have been low and purification of the product has been difficult.
GM van Wijk, KY Hostetler, H van den Bosch   +2 more
doaj  

Loss of lipin 1‐mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice

The FASEB Journal, 2018
Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride‐synthesis pathway and by regulating transcription factor activity.
G. Schweitzer, Sara L. Collier, Zhouji Chen, K. McCommis, S. Pittman, J. Yoshino, S. Matkovich, F. Hsu, R. Chrast, James M. Eaton, T. Harris, C. Weihl, B. Finck   +12 more
semanticscholar   +1 more source

Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols.

Journal of Lipid Research, 1991
Dietary fats are converted into chylomicron triacylglycerols via the 2-monoacylglycerol and phosphatidic acid pathways of acylglycerol formation. In view of the known positional and fatty acid specificity of the acyltransferases, the triacylglycerol ...
LY Yang, A Kuksis
doaj  

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes [PDF]

, 2020
BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders.
Davidson, Nicholas O, et al,, Meroni, Marica   +2 more
core   +1 more source

The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.

JCI Insight, 2018
Colon cancer is a devastating illness that is associated with gut inflammation. Here, we explored the possible role of lipin-1, a phosphatidic acid phosphatase, in the development of colitis-associated tumorigenesis.
C. Meana, G. García-Rostán, Lucía Peña, Gema Lordén, África Cubero, A. Orduña, Balázs Győrffy, Jesús Balsinde, M. Balboa   +8 more
semanticscholar   +1 more source

Neurodegenerative and Neurodevelopmental Roles for Bulk Lipid Transporters VPS13A and BLTP2

Movement Disorders, EarlyView.
Abstract Background Bridge‐like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early‐onset neurodevelopmental and later‐onset neurodegenerative diseases, including movement disorders.
Sarah D. Neuman, Rajan S. Thakur, Scott J. Gratz, Kate M. O'Connor‐Giles, Arash Bashirullah   +4 more
wiley   +1 more source

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

Journal of Clinical Investigation, 2018
The lipin phosphatidic acid phosphatase (PAP) enzymes are required for triacylglycerol (TAG) synthesis from glycerol 3-phosphate in most mammalian tissues.
Peixiang Zhang, Lauren S. Csaki, E. Ronquillo, Lynn Baufeld, J. Y. Lin, Alexis Gutierrez, Jennifer R. Dwyer, D. Brindley, L. Fong, P. Tontonoz, S. Young, K. Reue   +11 more
semanticscholar   +1 more source

Dysregulation of Monounsaturated Fatty Acids is Related to α‐Synuclein in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a neurodegenerative disease pathologically characterized by the presence of glial cytoplasmic inclusions (GCI) composed of α‐synuclein aggregates. In Parkinson's disease, increases in monounsaturated fatty acids (MUFA) in phospholipid membranes promote α‐synuclein binding, aggregation, and toxicity ...
Finula I. Isik, YuHong Fu, Russell Pickford, Qi Cheng, Yue Yang, Simon J.G. Lewis, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim   +8 more
wiley   +1 more source

Enzymatic synthesis of cytidine diphosphate diglyceride

Journal of Lipid Research, 1966
Evidence is presented for the enzymatic formation of cytidine diphosphate diglyceride in microsomal preparations from guinea pig liver according to the reaction:CTP + phosphatidic acid ⇌ CDP-diglyceride + P—O—P.Conditions have been found in which the ...
James R. Carter, Eugene P. Kennedy
doaj  

Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

Nature Communications, 2016
CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso, Carmen Valente, Lucia Laura Giordano, Angela Filograna, Guiling Li, Diego Circolo, Gabriele Turacchio, Vincenzo Manuel Marzullo, Luigi Mandrich, Mikhail A. Zhukovsky, Fabio Formiggini, Roman S. Polishchuk, Daniela Corda, Alberto Luini   +13 more
doaj   +1 more source