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Genetically Encoded Probes for Phosphatidic Acid
2012In addition to forming bilayers to separate cellular compartments, lipids participate in vesicular trafficking and signal transduction. Among others, phosphatidic acid (PA) is emerging as an important signaling molecule. The spatiotemporal distribution of cellular PA appears to be tightly regulated by localized synthesis and a rapid metabolism ...
Kassas, Nawal +6 more
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Phosphatidic acid- and phosphatidylserine-binding proteins
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids with well-recognized structural roles in cellular membranes. They are also signaling lipids since their regulated formation (or appearance) can constitute an important signal for downstream responses.
Catherine L, Stace +1 more
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
1. The properties of the aqueously dispersed phosphatidate-dependent phosphatidic acid phosphatase (EC 3.1.3.4) activities of rat lung have been studied in microsomal and cytosol preparations and compared with the properties of the membrane-bound phosphatidate-dependent activities. 2.
A, Yeung +4 more
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1. The properties of the aqueously dispersed phosphatidate-dependent phosphatidic acid phosphatase (EC 3.1.3.4) activities of rat lung have been studied in microsomal and cytosol preparations and compared with the properties of the membrane-bound phosphatidate-dependent activities. 2.
A, Yeung +4 more
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Recueil des Travaux Chimiques des Pays-Bas, 1954
AbstractThe preparation and some properties of three bisglycol‐phosphatidic acids, containing stearic, palmitic or myristic acid as component acid, are described.
J. van Gijzen, P. E. Verkade
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AbstractThe preparation and some properties of three bisglycol‐phosphatidic acids, containing stearic, palmitic or myristic acid as component acid, are described.
J. van Gijzen, P. E. Verkade
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Regulation of phosphatidic acid phosphohydrolase 1 by fatty acids
Lipids, 2002AbstractIn the starved state and during metabolic stress, free fatty acids (FFA) are the principal hepatic energy supply, undergoing β‐oxidation. Accordingly, it appears paradoxical that H‐A have been reported to increase the liver's esterification capacity by translocating the rate‐limiting enzyme phosphatidic acid phosphohydrolase (PAP‐1) from the ...
Elabbadi N, Day CP, Virden R, Yeaman SJ
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Metabolism of Phosphatidic Acid
1983In the first edition of the Handbook of Neurochemistry, Rossiter and Strickland1 reviewed the metabolism of phosphatidic acid in relation to the overall metabolism of phosphoglycerides, and Hawthorne and Kai2 described the metabolic relationship between phosphatidic acid and phosphoinositides.
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Phase Behavior of Phosphatidic Acid
1991Phosphatidic acids have a propensity for forming smectic (lamellar) phases. Under physiological conditions phosphatidic acids bear one negative charge/molecule and phosphatidate bilayers swell continuously with increasing water content similar to other negatively charged lipid bilayers.
C.-C. Yin, B.-Z. Lin, H. Hauser
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Assaying Plant Phosphatidic Acid Phosphatase Activity
2013Phosphatidic acid phosphatase (PAP; EC 3.1.3.4) catalyzes the dephosphorylation of phosphatidic acid (PA) to produce diacylglycerol (DAG) and inorganic phosphate. In seed plants, PA plays pivotal roles both as a precursor to membrane lipids and as a signaling molecule.
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