Results 11 to 20 of about 2,355 (98)

Functional Analysis of Sterol O-Acyltransferase Involved in the Biosynthetic Pathway of Pachymic Acid in Wolfiporia cocos

Molecules, 2021
Pachymic acid from Wolfiporia cocos possesses important medicinal values including anti-bacterial, anti-inflammatory, anti-viral, invigorating, anti-rejection, anti-tumor, and antioxidant activities.
Wenjun Zhu, Ying Liu, Jing Tang, Heping Liu, Naliang Jing, Fengfeng Li, Ran Xu, Shaohua Shu   +7 more
semanticscholar   +1 more source

Proteome analysis develops novel plasma proteins classifier in predicting the mortality of COVID‐19

Cell Proliferation
COVID‐19 has been a global concern for 3 years, however, consecutive plasma protein changes in the disease course are currently unclear. Setting the mortality within 28 days of admission as the main clinical outcome, plasma samples were collected from ...
Yifei Zeng, Yufan Li, Wanying Zhang, Huidan Lu, Siyi Lin, Wenting Zhang, Lexin Xia, Huiqun Hu, Yuanlin Song, Feng Xu   +9 more
semanticscholar   +1 more source

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

Nature Communications, 2020
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family.
Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, T. Luo, Lei Chen   +9 more
semanticscholar   +1 more source

New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440

Molecules, 2020
New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440.
Elyza Aiman Azizah Nur, Keisuke Kobayashi, A. Amagai, Taichi Ohshiro, H. Tomoda   +4 more
semanticscholar   +1 more source

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

bioRxiv, 2020
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family 1.
C. Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, K. Nishi, C. Chang, Ta-Yuan Chang, T. Luo, Lei Chen   +9 more
semanticscholar   +1 more source

The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice.

Biological and Pharmaceutical Bulletin, 2020
The fungal 13-membered cyclodepsipeptides, beauveriolides I and III, were previously reported to be atheroprotective activity in mouse models via inhibiting sterol O-acyltransferase (SOAT) activity.
Taichi Ohshiro, Satoshi Imuta, Ichiro Hijikuro, H. Yagyu, Takashi Takahashi, T. Doi, S. Ishibashi, H. Tomoda   +7 more
semanticscholar   +1 more source

Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets

bioRxiv
Objective Excess unesterified (free) cholesterol can induce formation of cholesterol crystals in hepatocyte lipid droplets. Presence of such crystal distinguishes metabolic dysfunction associated steatohepatitis (MASH) from simple steatosis and may ...
Jordan A Bairos, Uche Njoku, Maria Zafar, May G. Akl, Lei Li, Gunes Parlakgul, A. P. Arruda, Scott B. Widenmaier   +7 more
semanticscholar   +1 more source

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids

Communications Biology
Viruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis ...
A. Schöbel, Vinicius Pinho Dos Reis, Rabea Burkhard, Julia Hehner, Laura Schneider, Martin Schauflinger, G. Vieyres, E. Herker   +7 more
semanticscholar   +1 more source

Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1

International Journal of Molecular Sciences
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment.. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a ...
N. Farhat, D. Alexander, Kyli McKee, James Iben, Jorge L. Rodriguez-Gil, C. Wassif, N. Cawley, William E. Balch, F. Porter   +8 more
semanticscholar   +1 more source

Sterol-O acyltransferase 1 is inhibited by gga-miR-181a-5p and gga-miR-429-3p through the TGFβ pathway in endodermal epithelial cells of Japanese quail

bioRxiv, 2019
Nutrients are utilized and re-constructed by endodermal epithelial cells (EECs) in yolk sac membranes in avian species. Sterol-O acyltransferase 1 (SOAT1) is the key enzyme to convert cholesterol to cholesteryl ester for delivery to growing embryos ...
H. Lin, Chiao-Wei Lin, H. Mersmann, S. Ding   +3 more
semanticscholar   +1 more source