Results 11 to 20 of about 4,293 (162)

Effects of Dietary Phosphatidylcholine Supplementation on Growth Performance, Antioxidant Capacity, Fatty Acid Composition, and Lipid Metabolism of Juvenile Eriocheir sinensis‐Fed Different Oil Sources [PDF]

Aquaculture Nutrition, Volume 2025, Issue 1, 2025.
The present study investigates the effects of dietary phosphatidylcholine (PC) deficiency and its addition on growth and physiological and biochemical indicators of juvenile Eriocheir sinensis under different oil sources. There were no significant differences in the growth and feed utilization between the vegetable oils and fish oil (FO) groups under ...
Zhideng Lin, Xiaodan Wang, Xianyong Bu, Qincheng Huang, Han Wang, Erchao Li, Jianguang Qin, Liqiao Chen, Shivendra Kumar   +8 more
wiley   +2 more sources

Targeting PNPLA3 to Treat MASH and MASH Related Fibrosis and Cirrhosis [PDF]

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is caused by metabolic triggers and genetic predisposition. Among the genetic MASLD risk variants identified today, the common PNPLA3 148M variant exerts the largest effect size of MASLD heritability.
Daniel Lindén, Gregory Tesz, Rohit Loomba   +2 more
wiley   +2 more sources

Role of PNPLA3 in Hepatic Stellate Cells and Hepatic Cellular Crosstalk [PDF]

Liver International, Volume 45, Issue 4, April 2025.
ABSTRACT Aims Since its discovery, the patatin‐like phospholipase domain containing 3 (PNPLA3) (rs738409 C>G p.I148M) variant has been studied extensively to unravel its molecular function. Although several studies proved a causal relationship between the PNPLA3 I148M variant and MASLD development and particularly fibrosis, the pathological mechanisms ...
Maria Castanho Martins, Emmanuel Dauda Dixon, Giulia Lupo, Thierry Claudel, Michael Trauner, Krista Rombouts   +5 more
wiley   +2 more sources

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Journal of Clinical Investigation, 2022
Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver cancer
S. Kawamura, Y. Matsushita, Shigeyuki Kurosaki, Mizuki Tange, N. Fujiwara, Y. Hayata, Y. Hayakawa, Nobumi Suzuki, M. Hata, Mayo Tsuboi, T. Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Y. Hoshida, Atsushi Umemura, A. Eguchi, T. Ikenoue, Y. Hirata, M. Uesugi, R. Tateishi, K. Tateishi, M. Fujishiro, K. Koike, Hayato Nakagawa   +25 more
semanticscholar   +1 more source

Transmembrane Protein 68 Functions as an MGAT and DGAT Enzyme for Triacylglycerol Biosynthesis

International Journal of Molecular Sciences, 2023
Triacylglycerol (TG) biosynthesis is an important metabolic process for intracellular storage of surplus energy, intestinal dietary fat absorption, attenuation of lipotoxicity, lipid transportation, lactation and signal transduction in mammals ...
Yu Wang, Fansi Zeng, Zheng-Xiao Zhao, Lin He, Xiaohong He, H. Pang, Feifei Huang, Pingan Chang   +7 more
semanticscholar   +1 more source

Activation of phosphatidylcholine-sterol acyltransferase by human apolipoprotein E isoforms.

European Journal of Biochemistry, 1985
The reaction catalysed by phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) is believed to be the major source of cholesteryl ester in human plasma; the enzyme requires a protein activator.
A. Steinmetz, H. Kaffarnik, G. Utermann
semanticscholar   +1 more source

Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty Acid-mediated Cell Death*

Journal of Biological Chemistry, 2009
Deletion of the acyltransferases responsible for triglyceride and steryl ester synthesis in Saccharomyces cerevisiae serves as a genetic model of diseases where lipid overload is a component.
J. Garbarino, M. Padamsee, L. Wilcox, Peter Oelkers, Diana M D'Ambrosio, Kelly V. Ruggles, N. Ramsey, O. Jabado, Aaron R. Turkish, S. Sturley   +9 more
semanticscholar   +1 more source

Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186

Applied and Environmental Microbiology, 2023
Thraustochytrids are marine microorganisms expected to produce useful lipids. They synthesize polyunsaturated fatty acids and sterols and store them in lipid droplets as a form of triacylglycerol (TG) and sterol ester (SE), respectively.
Yohei Ishibashi, Shohei Sadamitsu, Yoshitomo Fukahori, Yuki Yamamoto, Rin Tanogashira, Takashi Watanabe, Masahiro Hayashi, Makoto Ito, N. Okino   +8 more
semanticscholar   +1 more source

Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy

Frontiers in Oncology, 2023
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
semanticscholar   +1 more source

Effects of site-directed mutagenesis at residues cysteine-31 and cysteine-184 on lecithin-cholesterol acyltransferase activity.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Native lecithin-cholesterol acyltransferase (LCAT; phosphatidylcholine-sterol acyltransferase; phosphatidylcholine:sterol O-acyltransferase, EC 2.3.1.43) protein, and LCAT in which either or both of the enzyme free cysteines had been replaced with ...
O. Francone, C. Fielding
semanticscholar   +1 more source