Results 21 to 30 of about 4,841 (163)

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations [PDF]

, 2011
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling.
A Cecile J W Janssens, Aaron Isaacs, Alan F Wright, Albert Hofman, Anatoly V Kirichenko, Andre Uitterlinden, Andrew A Hicks, Arne Pfeufer, Ayşe Demirkan, Ben A Oostra, CARDIoGRAM Consortium, Caroline Hayward, Carsten Gnewuch, CHARGE Consortium, Christopher J O'Donnell, Christopher P Nelson, Christopher S Franklin, Cornelia M van Duijn, Cristian Pattaro, DIAGRAM Consortium, EUROSPAN consortium, Fernando Rivadeneira, Francisco S Domingues, Gerd Schmitz, Gerhard Liebisch, Ghazal Zaboli, Harry Campbell, Igor Rudan, Inger Jonasson, Irene Pichler, Irina V Zorkoltseva, Ivana Kolcic, Jacqueline C M Witteman, James F Wilson, James Floyd, Jennifer Huffman, Joshua C Bis, Lennart C Karssen, Linda Broer, Lude Franke, Maksim Struchalin, Michael Preuss, Nicholas D Hastie, Nora Franceschini, Ozren Polasek, Peter P Pramstaller, Peter Ugocsai, Ritsert C Jansen, Sarah H Wild, Susan Campbell, Tatiana Axenovich, Thomas Meitinger, Ulf Gyllensten, Veronique Vitart, Wilmar Igl, Yurii S Aulchenko, Zrinka Biloglav, Åsa Johansson   +57 more
core   +13 more sources

Characterization of thraustochytrid-specific sterol O-acyltransferase: modification of DGAT2-like enzyme to increase the sterol production in Aurantiochytrium limacinum mh0186

Applied and Environmental Microbiology, 2023
Thraustochytrids are marine microorganisms expected to produce useful lipids. They synthesize polyunsaturated fatty acids and sterols and store them in lipid droplets as a form of triacylglycerol (TG) and sterol ester (SE), respectively.
Yohei Ishibashi, Shohei Sadamitsu, Yoshitomo Fukahori, Yuki Yamamoto, Rin Tanogashira, Takashi Watanabe, Masahiro Hayashi, Makoto Ito, N. Okino   +8 more
semanticscholar   +1 more source

Lipidomics in Health and Diseases - Beyond the Analysis of Lipids [PDF]

, 2014
published_or_final_versio
Fan, P, Li, M, Wang, Y
core   +1 more source

Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses

Communications Biology, 2021
The risks of non-alcoholic fatty liver disease (NAFLD) include obese and non-obese stresses such as chronic hepatitis C virus (HCV) infection, but the regulatory determinants remain obscure.
Hung-Yu Sun, Tzu-Ying Chen, Yuguang Tan, Chun‐Hsiang Wang, K. Young   +4 more
semanticscholar   +2 more sources

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma

Frontiers in Oncology, 2022
Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyan Guo, Shaolong Zhou, Zhuo Yang, Zian Li, Weihua Hu, Lirui Dai, Wulong Liang, Xinjun Wang   +7 more
semanticscholar   +1 more source

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency [PDF]

, 2005
Affiliation: CHU-Sainte-Justine, Université de MontréalTransport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are ...
Drouin, Éric, Levy, Emile, Marcil, Valérie, Peretti, Noël   +3 more
core   +2 more sources

Diagnosis of epithelial ovarian cancer using a combined protein biomarker panel

British Journal of Cancer, 2019
An early detection tool for EOC was constructed from analysis of biomarker expression data from serum collected during the UKCTOCS. This study included 49 EOC cases (19 Type I and 30 Type II) and 31 controls, representing 482 serial samples spanning ...
Matthew Russell, Ciaren Graham, A. D’Amato, A. Gentry-Maharaj, A. Ryan, Jatinderpal K Kalsi, A. Whetton, U. Menon, I. Jacobs, R. Graham   +9 more
semanticscholar   +1 more source