Results 161 to 170 of about 189,990 (387)

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

open access: yesAdvanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang   +8 more
wiley   +1 more source

Base exchange reactions of the phospholipids in rat brain particles

open access: yesJournal of Lipid Research, 1972
A particulate fraction from rat brain catalyzes the incorporation of [14C]choline, [14C]ethanolamine, and l-[1414C]serine into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, respectively.
Julian N. Kanfer
doaj  

Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant

open access: yesAdvanced Science, EarlyView.
Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan   +10 more
wiley   +1 more source

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

open access: yesAdvanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang   +17 more
wiley   +1 more source

Targeting Seipin to Alleviate Hepatic Steatosis in Zebrafish (Danio Rerio)

open access: yesAdvanced Science, EarlyView.
Seipin plays a crucial role in lipid metabolism. Seipin overexpression ameliorates high‐fat‐diet‐induced hepatic steatosis and enhances growth in zebrafish. Mechanistically, Seipin interacts with Plin2 to promote Plin2 degradation and enhances phosphatidylcholine synthesis via Seipin/CCTα/CHPT interactions.
Weijia Li   +6 more
wiley   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

open access: yesAdvanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui   +10 more
wiley   +1 more source

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