TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids. [PDF]
Yoo JE +9 more
europepmc +1 more source
ABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Yu Zhang +7 more
wiley +1 more source
Deciphering the causal effects of plasma metabolomics and lipids on breast cancer risk: a Mendelian randomization analysis. [PDF]
Zhou L +8 more
europepmc +1 more source
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle +6 more
wiley +1 more source
Integrative profiling of transcriptome and metabolome of skeletal muscle after endurance exercise in a high-fat diet. [PDF]
Jiang N +8 more
europepmc +1 more source
Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais +5 more
wiley +1 more source
Causal Effects of Diet on Atopic Dermatitis: A Mendelian Randomization Study Implicating Lipid Pathways and Clinical Implications. [PDF]
Wen X +6 more
europepmc +1 more source
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Author Correction: Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma. [PDF]
Yan W +12 more
europepmc +1 more source
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source

