Results 191 to 200 of about 114,039 (255)

Critical Illness-Related Alterations in Plasma Phosphatidylcholine Species Reveal Selective Induction of PC 32:0. [PDF]

Int J Mol Sci
Mester P, Pavel V, Schmid S, Höring M, Liebisch G, Müller M, Buechler C.   +6 more
europepmc   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Synthesis and <i>In Silico</i> and <i>In Vitro</i> Antitumor Potential of Novel Organochalcogens Derived from Azidothymidine and 2,4,6-Trichloro-1,3,5-triazine. [PDF]

ACS Omega
Rocha NS, da Silva SR, Carvalho BB, Wendt M, Dornelles L, Cossetin LF, Maia-do-Amaral BC, Rubert Nogueira-Librelotto D, da Rosa RM, Prestes AS, Mayer JCP, Barbosa NV, da Rocha JBT, Rodrigues OED.   +13 more
europepmc   +1 more source

Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang, Kevin Cho, Max C. Petersen, Kai E. Jones, Gary J. Patti, Janet B. McGill, Samantha A. DiGruccio   +6 more
wiley   +1 more source

Immune cell-mediated effects of plasma lipids on heart failure: A two-step, two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liu Z, Kwaku E, Cui Y, Xiong L, Li S, Zeng L, Du L, Wang K, Zheng J, Luo D, Zeng G, Yue R.   +11 more
europepmc   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Proteoglycan-Mimetic Bottle-Brush Polymer Brushes for Osteoarthritis Therapy: Lubrication Enhancement and Multifunctional Disease Modulation. [PDF]

Macromol Rapid Commun
Chen F, Zhao L, Zhang Y, Qin C, Liu Y.
europepmc   +1 more source

Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases

The FEBS Journal, EarlyView.
Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger, Markus Daniel Gerber, Torsten Ochsenreiter, Christoph von Ballmoos, André Schneider   +4 more
wiley   +1 more source

Early pregnancy metabolomic signatures for child growth trajectories: a prospective metabolome-wide association study. [PDF]

Am J Clin Nutr
Voong C, Ferrara A, Rosen Vollmar AK, Ngo AL, Chehab RF, Susarla SM, Barupal DK, Fiehn O, Zhu Y.   +8 more
europepmc   +1 more source