Results 161 to 170 of about 114,039 (255)

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

open access: yesRapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler   +7 more
wiley   +1 more source

Phosphatidylcholine — Mg2+ equilibria in a monolayer at the air/water interface

open access: yesOpen Chemistry, 2013
Petelska Aneta, Figaszewski Zbigniew
doaj   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

open access: yesResponsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan   +8 more
wiley   +1 more source

A Versatile Microfluidic Manufacturing Platform for Macroscale Multicore Hydrogel Capsules Toward Programmable Oral Delivery of Therapeutics

open access: yesSmall, EarlyView.
This study presents a microfluidic fabrication method for millimeter‐scale multicore hydrogel capsules containing multiple aqueous cores physically isolated by oil layers. These macrocapsules exhibit mechanical and chemical robustness effectively protecting cargos under simulated gastric conditions.
Hye‐Seon Jeong   +4 more
wiley   +1 more source

Reverse Micelles: The Gateway for Oral (Poly)Peptide Delivery

open access: yesSmall, EarlyView.
RM achieve superior oral peptide delivery through high loading capacity, strong lipophilicity, and a low‐hydration microenvironment that protects against enzymatic degradation. Meanwhile, dRM provides favorable permeation‐enhancing interactions and a consistent safety profile, collectively driving enhanced oral performance.
Marlene Ramona Schmidt   +2 more
wiley   +1 more source

Conquering the stronghold: Membrane‐targeting anti‐infective drug discovery

open access: yesSmart Molecules, EarlyView.
This perspective elucidates how XM‐01 and BLA combat infections through modulating pathogen membranes, disrupting biological processes, and potentiating therapeutics, offering cutting‐edge insights into anti‐infective drug mechanisms, innovations, and clinical translation.
Yanxu Hou   +4 more
wiley   +1 more source

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