Results 11 to 20 of about 123,253 (345)

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Nature, 2011
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death and morbidity worldwide.
Zeneng Wang, Elizabeth Klipfell, Brian J Bennett, Robert A. Koeth, B. Levison, Brandon Dugar, Ariel E. Feldstein, Earl B. Britt, Xiaoming Fu, Yoon-Mi Chung, Yuping Wu, P. Schauer, Jonathan D. Smith, H. Allayee, W. H. W. Tang, J. DiDonato, A. Lusis, Stanley L. Hazen   +17 more
semanticscholar   +1 more source

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

New England Journal of Medicine, 2013
BACKGROUND Recent studies in animals have shown a mechanistic link between intestinal microbial metabolism of the choline moiety in dietary phosphatidylcholine (lecithin) and coronary artery disease through the production of a proatherosclerotic ...
W. Tang, Zeneng Wang, B. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, S. Hazen   +7 more
semanticscholar   +1 more source

Phosphatidylcholine

Biophysical Journal, 1992
Two mono-cis-unsaturated phosphatidylcholine (PC) lipid molecules, having very different gel-liquid crystalline phase transition temperatures as a consequence of the relative positions of the double bond, exhibit PC:cholesterol phase diagrams that are very similar to each other and to that obtained previously for a fully saturated PC:cholesterol ...
Jenifer Thewalt, Myer Bloom
openaire   +3 more sources

Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity in Caenorhabditis elegans

Oxidative Medicine and Cellular Longevity, 2019
Phosphatidylcholine is one of the major phospholipids comprising cellular membrane and is known to have several health-promoting activities, including the improvement of brain function and liver repair.
So-Hyeon Kim, Bo-Kyoung Kim, Suhyeon Park, Sang-Kyu Park   +3 more
semanticscholar   +1 more source

Serum antibodies to phosphatidylcholine in MS [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2020
To evaluate the value of serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies reactive with phosphatidylcholine (PC) and lactosylceramide (LC) as biomarkers in MS.We developed an ultrasensitive ELISA technique to analyze serum IgG and IgM antibodies to LC and PC, which we used to analyze samples from 362 patients with MS, 10 patients with
Maria Cruz Sádaba, Veit Rothhammer, Úrsula Muñoz, Cristina Sebal, Esther Escudero, Pia Kivisäkk, Maria Isabel Garcia Sanchez, Guillermo Izquierdo, Stephen L. Hauser, Sergio E. Baranzini, Jorge R. Oksenberg, Roberto Álvarez-Lafuente, Rohit Bakshi, Howard L. Weiner, Francisco J. Quintana   +14 more
openaire   +6 more sources

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle

Frontiers in Physiology, 2022
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin and
William J. Valentine, William J. Valentine, Sherif A. Mostafa, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou, Hideo Shindou   +15 more
doaj   +1 more source

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation.

American Journal of Psychiatry, 2016
OBJECTIVE α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory synapses before birth. Choline at levels found in the amniotic fluid is an agonist at α7-nicotinic receptors. The authors conducted a double-blind placebo-controlled
Randal G. Ross, S. Hunter, M. C. Hoffman, Lizbeth McCarthy, Betsey M. Chambers, Amanda J. Law, S. Leonard, Gary O. Zerbe, R. Freedman   +8 more
semanticscholar   +1 more source

Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men.

American Journal of Clinical Nutrition, 2016
BACKGROUND The trimethylamine-containing nutrient phosphatidylcholine is the major dietary source for the gut microbiota metabolite trimethylamine-N-oxide (TMAO), which has been related to cardiovascular diseases (CVDs) and mortality.
Yan Zheng, Yanping Li, E. Rimm, F. Hu, C. Albert, K. Rexrode, J. Manson, L. Qi   +7 more
semanticscholar   +1 more source

Phosphatidylcholine: Greasing the Cholesterol Transport Machinery

Lipid Insights, 2016
Negative feedback regulation of cholesterol metabolism in mammalian cells ensures a proper balance of cholesterol with other membrane lipids, principal among these being the major phospholipid phosphatidylcholine (PC).
Thomas A. Lagace
semanticscholar   +1 more source

Expansion of Phosphatidylcholine and Phosphatidylserine/Phosphatidylcholine Monolayers by Differently Charged Amphiphiles [PDF]

Zeitschrift für Naturforschung C, 2001
Abstract Monolayer Technique, Nonionic Detergent, Erythrocyte Shape The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 °C ...
K Bialkowska, Henry Hägerstrand, Malgorzata Bobrowska-Hägerstrand   +2 more
openaire   +2 more sources