Results 31 to 40 of about 114,039 (255)

Determination of Phosphatidylcholine in Shrimp by High-Resolution Mass Spectrometry

, 2019
The molecular species of phosphatidylcholine from freshwater sources (Macrobranchium nipponense and Macrobranchium rosenbergii) and marine sources (Euphausia superba and Penaeus chinesis) were characterized by high-resolution mass spectrometry.
Yi Liang (110469), Yan Wang (15435), Xiaolin Wang (303612), Zheng Huang (274362), Li Zhou (54356)   +4 more
core   +1 more source

M28 family peptidase derived from Peribacillus frigoritolerans initiates trained immunity to prevent MRSA via the complosome-phosphatidylcholine axis

Gut Microbes
Methicillin-resistant Staphylococcus aureus (MRSA) represents a major global health threat due to its resistance to conventional antibiotics. The commensal microbiota maintains a symbiotic relationship with the host, playing essential roles in metabolism,
Cheng-Kai Zhou, Zhen-Zhen Liu, Zi-Ran Peng, Xue-Yue Luo, Xiao-Mei Zhang, Jian-Gang Zhang, Liang Zhang, Wei Chen, Yong-Jun Yang   +8 more
doaj   +1 more source

Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients [PDF]

, 2011
Background Patients with Adult Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid.
Baritussio A, Massara Lorenza, Baritussio, Aldo, Simonato, Manuela, Lorenza Dalla Massara, Sabina Rizzi, Rizzi, Sabina, M. Simonato, Rossi S, Rizzi Sabina, Simonato Manuela, Dalla Massara L, Massara, Lorenza, S. Rossi, COGO, Paola, Ori Carlo, Baritussio Aldo, CARNIELLI, VIRGILIO, Aldo Baritussio, L. Vedovelli, C. Ori, Sandra Rossi, Cogo Paola E, A. Baritussio, Rossi, Sandra, Paola E Cogo, Vedovelli, Luca, Manuela Simonato, Simonato M, Vedovelli L, Carlo Ori, Ori C, Vedovelli Luca, Cogo P.E., Carnielli Virgilio P, L. Dalla Massara, V. P. Carnielli, Ori, Carlo, Virgilio P Carnielli, Luca Vedovelli, Rizzi S, Carnielli, Virgilio P., Rossi Sandra, S. Rizzi, P. E. Cogo   +44 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Integrative lipidomic features identify plasma lipid signatures in chronic urticaria

Frontiers in Immunology, 2022
Chronic urticaria (CU) is a chronic inflammatory skin disease mainly mediated by mast cells. Lipids exert essential functions in biological processes; however, the role of lipids in CU remains unclear.
Jie Li, Jie Li, Jie Li, Jie Li, Liqiao Li, Liqiao Li, Liqiao Li, Liqiao Li, Runqiu Liu, Runqiu Liu, Runqiu Liu, Runqiu Liu, Lei Zhu, Lei Zhu, Lei Zhu, Lei Zhu, Bingjing Zhou, Bingjing Zhou, Bingjing Zhou, Bingjing Zhou, Yi Xiao, Yi Xiao, Yi Xiao, Yi Xiao, Guixue Hou, Liang Lin, Xiang Chen, Xiang Chen, Xiang Chen, Xiang Chen, Cong Peng, Cong Peng, Cong Peng, Cong Peng   +33 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Phosphatidylcholine in Intestinal Mucus Protects against Mucosal Invasion of Microbiota and Consequent Inflammation

Livers
Intestinal mucus serves as the first line barrier within the mucosa to protect against microbiota attack due to its water-repellent properties, which are the result of the high abundance of phosphatidylcholine bound to mucins.
Wolfgang Stremmel, Ralf Weiskirchen
doaj   +1 more source

Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells

Frontiers in Immunology, 2022
To become resistant, cancer cells need to activate and maintain molecular defense mechanisms that depend on an energy trade-off between resistance and essential functions.
Renata de Freitas Saito, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger Chammas   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source