Results 11 to 20 of about 111,710 (302)

Anti-inflammatory Effects of Phosphatidylcholine [PDF]

Journal of Biological Chemistry, 2007
We recently showed that mucus from patients with ulcerative colitis, a chronic inflammatory disorder of the colon, is characterized by a low level of phosphatidylcholine (PC) while clinical studies reveal that therapeutic addition of PC using slow release preparations is beneficial. The positive role of PC in this disease is still elusive.
Treede, Irina, Braun, Annika, Sparla, Richard, Kuehnel, Mark, Giese, Thomas, Turner, Jerrold R., Anes, Elsa, Kulaksiz, Hasan, Fuellekrug, Joachim, Stremmel, Wolfgang, Griffiths, Gareth, Ehehalt, Robert   +11 more
openaire   +4 more sources

Effects of diacylglycerols on conformation of phosphatidylcholine headgroups in phosphatidylcholine/phosphatidylserine bilayers [PDF]

Biophysical Journal, 1995
The effects of five diacylglycerols (DAGs), diolein, 1-stearoyl,2-arachidonoyl-sn-glycerol, dioctanoylglycerol, 1-oleoyl,2-sn-acetylglycerol, and dipalmitin (DP), on the structure of lipid bilayers composed of mixtures of phosphatidylcholine and phosphatidylserine (4:1 mol/mol) were examined by 2H nuclear magnetic resonance (NMR ...
Goldberg, E.M., Lester, D.S., Borchardt, D.B., Zidovetzki, R.   +3 more
openaire   +3 more sources

Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes [PDF]

, 2011
Stable isotope labelling of lipid precursors coupled with mass spectrometry-based lipidomic analyses and determination of isotope enrichment in substrate, intermediate and product pools provide the parameters needed to determine absolute flux rates ...
Grielof Koster, Koster, G., Howard W. Clark, Clark, Howard, Anthony D. Postle, Neil G. Henderson, Henderson, N.J., Alan N. Hunt, Postle, A.D., Hunt, A.N.   +9 more
core   +1 more source

Series of Concentration-Induced Phase Transitions in Cholesterol/Phosphatidylcholine Mixtures [PDF]

, 2013
In lipid membranes, temperature-induced transition from gel-to-fluid phase increases the lateral diffusion of the lipid molecules by three orders of magnitude.
István P. Sugár, Parkson L.-G. Chong, Sugár, István P., Chong, Parkson L.-G., István Simon, Chong, Parkson Lee-Gau, Simon, István   +6 more
core   +1 more source

Phosphatidylcholine synthesis for incorporation into membranes or for secretion as plasma lipoproteins by Golgi membranes of rat liver.

Journal of Lipid Research, 1987
Phosphatidylcholine, the major phospholipid of very low density lipoproteins, is packaged with triglyceride in the Golgi cisternae. CTP-phosphocholine cytidyltransferase and CDP-choline phosphotransferase activities of Golgi subfractions were higher than
J A Higgins, J K Fieldsend
doaj   +1 more source

Hemolysis of Rat Erythrocytes by Replacement of the Natural Phosphatidylcholine by Various Phosphatidylcholines [PDF]

European Journal of Biochemistry, 1980
Vesicles of a variety of types of phosphatidylcholine have been shown to be suitable donors of phosphatidylcholine to intact rat erythrocytes in the presence of a specific phosphatidylcholine exchange protein. Coincident with the progression of phosphatidylcholine exchange is the onset of hemolysis, occurring at degrees of exchange characteristic for ...
Lange, L.G., van Meer, G., op den Kamp, J.A.F., van Deenen, L.L.M.   +3 more
openaire   +3 more sources

Barbiturate Interaction with Phosphatidylcholine [PDF]

Proceedings of the National Academy of Sciences, 1972
A hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates. The nitrogenbound proton of the barbiturate and the orthophosphate moiety of the phosphatidylcholine molecule ...
R F, Novak, T J, Swift
openaire   +2 more sources

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Walker, Ann P., Hannun, Y.A., Bloom, SL, Walker, A.P., Sewell, GW, Segal, A.W., Koster, Grielof, Sewell, Gavin W., Hannun, Yusuf A., Koster, G, Vega, R., Bielawski, Jacek, Segal, Anthony W., Koster, G., Smith, P.J., Han, X., Rahman, FZ, Postle, AD, Goss, V., Vega, R, Hannun, YA, Postle, Anthony D., Rahman, Farooq Z., Bloom, Stuart L., Walker, AP, Han, X, Vega, Roser, Smith, Philip J., Smith, PJ, Rahman, F.Z., Bielawski, J, Bloom, S.L., Bielawski, J., Goss, V, Goss, Victoria, Han, Xianlin, Sewell, G.W., Segal, AW   +37 more
core   +1 more source

PHARMACOEPIDEMIOLOGICAL EVALUATION OF HEPATOTROPIC THERAPY IN REAL CLINICAL PRACTICE

Фармакоэкономика, 2015
Chronic liver diseases are a serious problem and a common cause of suffering and death in all countries. Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver diseases.
D. V. Blinov, U. V. Zimovina, T. I. Ushakova   +2 more
doaj   +1 more source

Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux

Journal of Lipid Research, 2004
Alveolar type II lung epithelia produce surfactant, an essential surface-active material highly enriched with disaturated phosphatidylcholine (DSPC), which requires a key regulatory enzyme, CTP:phosphocholine cytidylyltransferase α (CCTα), for its ...
Jiming Zhou, Yong You, Alan J. Ryan, Rama K. Mallampalli   +3 more
doaj   +1 more source