Results 11 to 20 of about 114,039 (255)

Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes [PDF]

, 2011
Stable isotope labelling of lipid precursors coupled with mass spectrometry-based lipidomic analyses and determination of isotope enrichment in substrate, intermediate and product pools provide the parameters needed to determine absolute flux rates ...
Grielof Koster, Koster, G., Howard W. Clark, Clark, Howard, Anthony D. Postle, Neil G. Henderson, Henderson, N.J., Alan N. Hunt, Postle, A.D., Hunt, A.N.   +9 more
core   +1 more source

Unusual Lipid Components of Legionella gormanii Membranes

Metabolites, 2022
Legionella spp. cause Legionnaires’ disease with pneumonia as the predominant clinical symptom. L. gormanii is the second most prevalent causative agent of community-acquired pneumonia after L. pneumophila. The study aimed to characterize the lipidome of
Elżbieta Chmiel, Christina E. Galuska, Piotr Koper, Bożena Kowalczyk, Teresa Urbanik-Sypniewska, Marta Palusińska-Szysz, Beate Fuchs   +6 more
doaj   +1 more source

Phosphatidylcholine synthesis for incorporation into membranes or for secretion as plasma lipoproteins by Golgi membranes of rat liver.

Journal of Lipid Research, 1987
Phosphatidylcholine, the major phospholipid of very low density lipoproteins, is packaged with triglyceride in the Golgi cisternae. CTP-phosphocholine cytidyltransferase and CDP-choline phosphotransferase activities of Golgi subfractions were higher than
J A Higgins, J K Fieldsend
doaj   +1 more source

Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes

Biomolecules, 2023
Lysosomes are degradative organelles that facilitate the removal and recycling of potentially cytotoxic materials and mediate a variety of other cellular processes, such as nutrient sensing, intracellular signaling, and lipid metabolism.
Jacob M. Albright, Matthew J. Sydor, Jonathan Shannahan, Christina R. Ferreira, Andrij Holian   +4 more
doaj   +1 more source

The Phospholipid N-Methyltransferase and Phosphatidylcholine Synthase Pathways and the ChoXWV Choline Uptake System Involved in Phosphatidylcholine Synthesis Are Widely Conserved in Most, but Not All Brucella Species

Frontiers in Microbiology, 2021
The brucellae are facultative intracellular bacteria with a cell envelope rich in phosphatidylcholine (PC). PC is abundant in eukaryotes but rare in prokaryotes, and it has been proposed that Brucella uses PC to mimic eukaryotic-like features and avoid ...
Beatriz Aragón-Aranda, Leyre Palacios-Chaves, Miriam Salvador-Bescós, María Jesús de Miguel, María Jesús de Miguel, Pilar M. Muñoz, Pilar M. Muñoz, Miguel Ángel Vences-Guzmán, Amaia Zúñiga-Ripa, Leticia Lázaro-Antón, Christian Sohlenkamp, Ignacio Moriyón, Maite Iriarte, Raquel Conde-Álvarez   +13 more
doaj   +1 more source

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. [PDF]

, 2012
Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
Hannun, Y.A., Bloom, SL, Walker, A.P., Sewell, GW, Segal, A.W., Koster, G, Vega, R., Koster, G., Smith, P.J., Han, X., Rahman, FZ, Postle, AD, Goss, V., Vega, R, Hannun, YA, Postle, Anthony D., Walker, AP, Han, X, Smith, PJ, Rahman, F.Z., Bielawski, J, Bloom, S.L., Bielawski, J., Goss, V, Sewell, G.W., Segal, AW   +25 more
core   +1 more source

Hearing Loss in Alzheimer’s Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles

Cells, 2020
Recent data have found that aging-related hearing loss (ARHL) is associated with the development of Alzheimer’s Disease (AD). However, the nature of the relationship between these two disorders is not clear. There are multiple potential factors that link
Daniel A. Llano, Lina K. Issa, Priya Devanarayan, Viswanath Devanarayan, Alzheimer’s Disease Neuroimaging Initiative (ADNI)   +4 more
doaj   +1 more source

Protective Effects of Phosphatidylcholine against Hepatic and Renal Cell Injury from Advanced Glycation End Products

Medicina, 2022
Background and Objectives: Receptors of the advanced glycation products (RAGE) are activated to promote cell death and contributes to chronic diseases such as diabetes and inflammation. Advanced glycation end products (AGEs), which interact with RAGE are
Jihye Choi, Inbong Song, Sangmin Lee, Myungjo You, Jungkee Kwon   +4 more
doaj   +1 more source

Age-related changes in antigen-specific natural antibodies are influenced by sex

Frontiers in Immunology, 2023
IntroductionNatural antibody (NAb) derived from CD5+ B-1 cells maintains tissue homeostasis, controls inflammation, aids in establishing long-term protective responses against pathogens, and provides immediate protection from infection.
Sarah E. Webster, Naomi L. Tsuji, Michael J. Clemente, Michael J. Clemente, Nichol E. Holodick, Nichol E. Holodick   +5 more
doaj   +1 more source

Base exchange reactions of the phospholipids in rat brain particles

Journal of Lipid Research, 1972
A particulate fraction from rat brain catalyzes the incorporation of [14C]choline, [14C]ethanolamine, and l-[1414C]serine into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, respectively.
Julian N. Kanfer
doaj   +1 more source