Results 191 to 200 of about 155,795 (339)

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca   +2 more
wiley   +1 more source

A Pomegranate Polyphenol Extract Suppresses the Microbial Production of Proatherogenic Trimethylamine (TMA) in an In Vitro Human Colon Model

open access: yesMolecular Nutrition &Food Research, EarlyView.
Trimethylamine N‐oxide (TMAO) is associated with various cardiometabolic and other diseases and can cause thrombosis and vascular inflammation. Dietary l‐carnitine and choline are metabolized by gut microbiota to trimethylamine (TMA), which is oxidized to TMAO in the liver.
Julia E. Haarhuis   +6 more
wiley   +1 more source

Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia. [PDF]

open access: yesSignal Transduct Target Ther
Sun J   +14 more
europepmc   +1 more source

Impact of Nutrition on Sphingolipid‐Regulated Physiology: A Review

open access: yesMolecular Nutrition &Food Research, EarlyView.
Sphingolipids (SLs) play a role in multiple, if not all physiological processes. This review summarizes the current knowledge on SLs and their role in (patho‐) physiological processes with special regard to dietary and transgenerational effects. Image was created with BioRender.com.
Jonas Voß   +2 more
wiley   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

open access: yesMolecular Nutrition &Food Research, EarlyView.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott   +12 more
wiley   +1 more source

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