Results 291 to 300 of about 156,498 (339)

Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein

open access: yesThe FEBS Journal, EarlyView.
An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj   +12 more
wiley   +1 more source

Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study. [PDF]

open access: yesDiabetol Metab Syndr
Su J   +13 more
europepmc   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

open access: yesInternational Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian   +2 more
wiley   +1 more source

Multi‐pathway‐driven hepatic protection: Semaglutide combined with HIIT counteracts diabetic liver injury in db/db mice

open access: yesJournal of Diabetes Investigation, EarlyView.
This study reveals that the new drug semaglutide combined with high‐intensity interval training is significantly better than a single drug in improving liver metabolic abnormalities in type 2 diabetes. Untargeted metabolomics studies showed that the synergistic effect was mainly achieved by regulating key pathways such as the TCA cycle, amino acid ...
Wenjun Yu   +6 more
wiley   +1 more source

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

open access: yesJournal of Microscopy, EarlyView.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid   +3 more
wiley   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

open access: yesPlant Biotechnology Journal, EarlyView.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

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