Results 91 to 100 of about 1,479 (250)

Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition

Physiological Reports
Pheochromocytoma and paraganglioma with a succinate dehydrogenase B subunit (SDHB) pathogenic variant are associated with a significant chance for metastasis.
Abdel A. Alli, Niharika Bala, Yiling Xu, Nancy D. Denslow, Hans K. Ghayee   +4 more
doaj   +1 more source

Genetic causality of lipidomic and immune cell profiles in ischemic stroke

Frontiers in Neurology
BackgroundIschemic stroke (IS) is a global health issue linked to lipid metabolism and immune cell responses. This study uses Mendelian randomization (MR) to identify genetic risk factors for IS subtypes using comprehensive genetic data from lipidomic ...
Haohao Chen, Haohao Chen, Zequn Zheng, Zequn Zheng, Xiaorui Cai, Shunxian Li, Manli Chen, Jiaming Wu, Wenzhen He, Fenfei Gao   +9 more
doaj   +1 more source

Additional file 2 of Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach

, 2023
Additional file 2: Tab. S2. The intra-coefficient of variation (CV) among all identified phosphatidylethanolamines in our study after eight attempts of quality ...
Ximeng Wang (793633), Zhongwei Huang (3357071), Yap Seng Chong (242795), Jerry Kok Yen Chan (9364250), Ling-Jun Li (15272011), Kok Hian Tan (8703684), Mohammad L. Rahman (5623382), Liang Cui (446525), Johan G. Eriksson (7726124), Cuilin Zhang (132154)   +9 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Sex‐Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sex disparities exist in cardiometabolic diseases. Metabolomic profiling offers insight into disease mechanisms, as the metabolome is influenced by environmental and genetic factors. We identified metabolites associated with sex and determined
Catharine A. Couch, Zsuzsanna Ament, Amit Patki, Naruchorn Kijpaisalratana, Varun Bhave, Alana C. Jones, Nicole D. Armstrong, Mary Cushman, W. Taylor Kimberly, M. Ryan Irvin   +9 more
doaj   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Study on dynamic alterations of plasma lipid profiles during disease progression in combined allergic rhinitis and asthma syndrome based on lipidomics

Frontiers in Immunology
Combined allergic rhinitis and asthma syndrome (CARAS) involves complex interactions between inflammation and lipid metabolism. This study recruited 90 CARAS patients admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from ...
Yanmin Shi, Yanmin Shi, Yanmin Shi, Yiting Li, Zifan Cheng, JiaJia Wang, JiaJia Wang, JiaJia Wang, Suyun Li, Suyun Li, Suyun Li, Yang Xie, Yang Xie, Yang Xie   +13 more
doaj   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure [PDF]

, 2012
Contains fulltext : 107961.pdf (Publisher’s version ) (Open Access)Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Dinkla, S., Brock, R.E., Dinkla, S, Cluitmans, JC, Fuchs, B, Joosten, I, Fransen, J., Tomelleri, C, Verdurmen, W.P.R., Bosman, G.J.C.G.M., Wessels, K, Schiller, J., Wessels, K., Brock, R, Fuchs, B., Verdurmen, WP, Joosten, I., Bosman, GJ, Cluitmans, J.C.A., Schiller, J, Tomelleri, C., Fransen, J   +21 more
core   +2 more sources

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source