Results 91 to 100 of about 8,364 (275)

Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death [PDF]

: The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated fatty acids (PUFA) attached predominantly at the sn2 position, and non‐oxidizable saturated/monounsaturated acids (SFA/MUFA)
Bahar, Ivet, Yang, Xin, Dar, Haider H, Souryavong, Austin B, Gu, Wei, Tyurina, Yulia Y, Amoscato, Andrew A, Beharier, Ofer, Karumanchi, S Ananth, Wenzel, Sally E, Kagan, Valerian E, Sadovsky, Yoel, Mallampalli, Rama K, Bayir, Hülya, Mikulska‐Ruminska, Karolina, Bunimovich, Yuri L, Tyurin, Vladimir A, Kapralov, Alexander A, Holman, Theodore R, St Croix, Claudette M, Samovich, Svetlana N, VanDemark, Andrew P   +21 more
core   +4 more sources

Genetic causality of lipidomic and immune cell profiles in ischemic stroke

Frontiers in Neurology
BackgroundIschemic stroke (IS) is a global health issue linked to lipid metabolism and immune cell responses. This study uses Mendelian randomization (MR) to identify genetic risk factors for IS subtypes using comprehensive genetic data from lipidomic ...
Haohao Chen, Haohao Chen, Zequn Zheng, Zequn Zheng, Xiaorui Cai, Shunxian Li, Manli Chen, Jiaming Wu, Wenzhen He, Fenfei Gao   +9 more
doaj   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Sex‐Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sex disparities exist in cardiometabolic diseases. Metabolomic profiling offers insight into disease mechanisms, as the metabolome is influenced by environmental and genetic factors. We identified metabolites associated with sex and determined
Catharine A. Couch, Zsuzsanna Ament, Amit Patki, Naruchorn Kijpaisalratana, Varun Bhave, Alana C. Jones, Nicole D. Armstrong, Mary Cushman, W. Taylor Kimberly, M. Ryan Irvin   +9 more
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Investigating the association of the plasma lipidomic profile with cognitive performance and genetic risk in the PsyCourse study

Translational Psychiatry
Although lipid biology may play a key role in the pathophysiology of mental health disorders such as schizophrenia (SCZ) and bipolar disorder (BD), the nature of this interplay and how it could shape phenotypic presentation, including cognitive ...
Mojtaba Oraki Kohshour, Sergi Papiol, Anna Tkachev, Elena Stekolshchikova, Kristina Adorjan, Monika Budde, Urs Heilbronner, Maria Heilbronner, Janos L. Kalman, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Fanny Senner, Thomas Vogl, Jens Wiltfang, Eva Z. Reininghaus, Georg Juckel, Udo Dannlowski, Andreas J. Fallgatter, Carsten Spitzer, Max Schmauß, Martin von Hagen, Peter Falkai, Philipp Khaitovich, Thomas G. Schulze, Eva C. Schulte   +24 more
doaj   +1 more source

N-aldehyde-modified phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-acyl phosphatidylethanolamine phospholipase D

Journal of Lipid Research
N-acyl phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) hydrolyzes phosphatidylethanolamines (PEs) where the headgroup nitrogen has been enzymatically modified with acyl chains of four carbons or longer (N-acyl-PEs or NAPEs).
Reza Fadaei, Annie C. Bernstein, Andrew N. Jenkins, Allison G. Pickens, Jonah E. Zarrow, Abdul-Musawwir Alli-Oluwafuyi, Keri A. Tallman, Sean S. Davies   +7 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Comparative Phospholipid Profiles of Control and Glaucomatous Human Trabecular Meshwork [PDF]

, 2013
We present identification, comparison of differences between control and glaucomatous eyes, and analyses of unique phospholipids (phosphatidylcholines, phosphatidylserines, phosphatidylethanolamines, and phosphatidylinositols) in the trabecular meshwork ...
Aribindi, Katyayini, Lee, Richard K, Guerra, Yenifer, Bhattacharya, Sanjoy K   +3 more
core   +1 more source