Results 121 to 130 of about 8,364 (275)

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Glycerophospholipid fatty acid remodeling optimizes lipid nutrition and volatile organic compound composition in freshwater fish with linolenic acid intervention

Food Chemistry: X
To investigate α-linolenic acid (ALA) intervention effects on lipid remodeling and volatile organic compounds (VOCs) in Cyprinus carpio, fish were fed soybean oil (SO, 5.37 % ALA) and flaxseed oil (SL, 32.66 % ALA) diets for 30 weeks.
Zijie He, Junli Wang, Yun Wei, Xiao Yan, Yuanyou Li, Guoxing Nie, Dizhi Xie   +6 more
doaj   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Integrated lipidomics and flavoromics approach elucidates the antioxidant-mediated preservation mechanisms in silver carp (Hypophthalmichthys molitrix) visceral fish oil during thermal processing

Food Chemistry: X
Integrated lipidomics and flavoromics were employed to elucidate the mechanism of antioxidants in mitigating flavor deterioration of fish oil from silver carp viscera.
Bin Peng, Linchuan Xu, Liping Yuan, Chengwei Yu, Mingming Hu, Bizheng Zhong, Zongcai Tu, Jinlin Li   +7 more
doaj   +1 more source

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, EarlyView.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Hybrid Quatsome‐Encapsulated Silver Nanoparticles as Stable Plasmonic Substrates for Surface‐Enhanced Raman Scattering

Journal of Raman Spectroscopy, EarlyView.
In this work, silver nanoparticles encapsulated within quatsome membranes have shown to preserve their plasmonic properties for at least 165 days without aggregation. These hybrid nanostructures enable strong SERS enhancement of pyrene and Prodan by confining the molecules within a few nanometers from the silver surface.
Renato Cezar Peramezza Ribeiro, Caio Hiroaki Miyake, Pedro Henrique Figueiredo Backes Costa, Jhenifer Hallen Braga Mauricio, Ana Luiza Correa Januário, Diogo Soga, Evandro Luiz Duarte, Márcia de Almeida Rizzutto, Rômulo Augusto Ando, Antonio Rodrigues da Cunha, Erix Alexander Milán‐Garcés   +10 more
wiley   +1 more source

Membrane vectorial lipidomic features of coral host cells’ plasma membrane and lipid profiles of their endosymbionts Cladocopium

Communications Biology
The symbiotic relationships between coral animal host and autotrophic dinoflagellates are based on the mutual exchange and tight control of nutritional inputs supporting successful growth.
Tatyana V. Sikorskaya, Ekaterina V. Ermolenko, Taliya T. Ginanova, Andrey V. Boroda, Kseniya V. Efimova, Mikhail Bogdanov   +5 more
doaj   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

x‐Ray Structure of Streptomyces avermitilis Phospholipase D Reveals a Ca2+‐Stabilized Expanded Active‐Site Cleft Adapted for Phospholipid Binding

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Phospholipase D (PLD) catalyzes the hydrolysis of phospholipids to generate phosphatidic acid and free head groups such as choline. Among bacterial PLD enzymes, Streptomyces chromofuscus PLD (SchPLD), a member of the alkaline phosphatase D (PhoD) superfamily, exhibits unique Ca2+‐dependent phospholipase activity.
Yoshiaki Yasutake, Tatsuya Hirata, Shunsuke Nomura, Kenji Konishi, Kazunari Yoneda, Shin‐ichi Sakasegawa, Haruhiko Sakuraba   +6 more
wiley   +1 more source

Multi-omics analysis of flavor and quality modulation in dry-fermented sausages with textured pea protein

Food Chemistry: X
As textured pea protein (TPP) emerges as a sustainable strategy for plant-based meat analogues, its influence on flavor precursors and the resulting volatile profile and sensory attributes remains underexplored.
Ying Li, Jian Zhang, Xin Liu, Danni Zhang, Imre Blank, Xiaoxiao Feng, Ninglong Zhang, Zheng Liu, Xi Ding, Chunbao Li, Xinglian Xu, Changbo Tang, Guanghong Zhou, Yuan Liu   +13 more
doaj   +1 more source