Results 21 to 30 of about 35,571 (360)

ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer [PDF]

Nature Communications, 2012
ATP-binding cassette (ABC) transporters comprise a superfamily of proteins, which actively transport a variety of compounds across cell membranes. Mammalian and most eukaryotic ABC transporters function as exporters, flipping or extruding substrates from the cytoplasmic to the extracellular or lumen side of cell membranes.
Quazi, Faraz, Lenevich, Stepan, Molday, Robert S.   +2 more
openaire   +2 more sources

Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure

Environment International, 2022
Health risks caused by crucial environmental carcinogens N-nitrosamines triggered ubiquitous attention. As the liver exerted vital function through metabolic process, lipid metabolism disorders have been confirmed as potential drivers for toxicological ...
Hu Zhang, Lu Lu, Chao Zhao, Qiwei Liu, Qian Zhou, Ying Zhang, Yuepu Pu, Shizhi Wang, Ran Liu, Lihong Yin   +9 more
doaj   +1 more source

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh, A Scalbert, AK Chavali, Andris Jankevics, BO Keller, C Bern, C Christin, CC HsuChen, D Kumar, David G. Watson, DS Wishart, E Cauchetier, E Fahy, F Chappuis, F Hong, FR Opperdoes, G Barratt, Graham H. Coombs, H Ogata, HC Maltezou, HJ Atherton, HP de Koning, HW Murray, J Alvar, J Trygg, J Vandesompele, JC Mottram, Jean-Claude Dujardin, JV Olsen, K Zhang, K Zhang, Kirstyn Brunker, KW Tintaya, M Basselin, M Basselin, M Rakotomanga, MA Basinger, MA Doyle, MA Kamleh, MA Kamleh, MB Eisen, MK Wassef, MZ Alam, N Mbongo, N Van Meirvenne, R Breitling, R Breitling, R Breitling, RA Scheltema, RA Scheltema, RA Scheltema, Rainer Breitling, Richard A. Scheltema, Ruben t'Kindt, S Rijal, S Sundar, Saskia Decuypere, Suman Rijal, T Laurent, T Naderer, Timothy G. Geary, VP Shah, W Windig, WB Dunn   +63 more
core   +10 more sources

Spatial distribution of glycerophospholipids in the ocular lens. [PDF]

PLoS ONE, 2011
Knowledge of the spatial distribution of lipids in the intraocular lens is important for understanding the physiology and biochemistry of this unique tissue and for gaining a better insight into the mechanisms underlying diseases of the lens.
Jaroslav Pól, Veronika Vidová, Tuulia Hyötyläinen, Michael Volný, Petr Novák, Martin Strohalm, Risto Kostiainen, Vladimír Havlíček, Susanne K Wiedmer, Juha M Holopainen   +9 more
doaj   +1 more source

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

Redox Biology, 2021
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic ...
Tamil S. Anthonymuthu, Yulia Y. Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Vladimir A. Tyurin, Fatma B. Cinemre, Haider H. Dar, Andrew P. VanDemark, Theodore R. Holman, Yoel Sadovsky, Brent R. Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E. Kagan   +15 more
doaj   +1 more source

Increased ω6-Containing Phospholipids and Primary ω6 Oxidation Products in the Brain Tissue of Rats on an ω3-Deficient Diet. [PDF]

PLoS ONE, 2016
Polyunsaturated fatty acyl (PUFA) chains in both the ω3 and ω6 series are essential for normal animal brain development, and cannot be interconverted to compensate for a dietary deficiency of one or the other.
Paul H Axelsen, Robert C Murphy, Miki Igarashi, Stanley I Rapoport   +3 more
doaj   +1 more source

Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. [PDF]

, 2016
ObjectiveTo determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis
Boyle, David, Guma, Monica, Kavanaugh, Arthur, Lodi, Alessia, Sweeney, Shannon R, Tiziani, Stefano, Wang, Bo   +6 more
core   +2 more sources

Phosphatidylethanolamine Levels and Regulation of Phosphatidylethanolamine N- Methyltransferase

Journal of Biological Chemistry, 1989
The activity of phosphatidylethanolamine (PE) N-methyltransferase in liver microsomes, measured using endogenous microsomal PE as a substrate, was elevated 2-fold in the choline-deficient state. However, methyltransferase activity assayed in the presence of a saturating concentration of phosphatidyl-N-mono-methylethanolamine or microsomal PE was ...
N D, Ridgway, Z, Yao, D E, Vance
openaire   +2 more sources

Mouse mitochondrial lipid composition is defined by age in brain and muscle [PDF]

, 2017
Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges.
Al-Gubory, Arnould, Becker, Brügger, Chakrabarti, Chakrabarti, Cherkaoui-Malki, Coleman, Corcelli, Daum, Eckert, Goto, Gottlieb, Ha, Han, Harman, Hulbert, Klein-Seetharaman, Koehler, Koltai, Kristal, Lavialle, Liu, Liu, Madeo, McQuibban, Moreau, Nakaya, Nicolaou, Nunnari, Osiewacz, Patel, Pufa, Rea, Rudich, Schägger, Sonninen, Tasseva, Vaz, Verkhratsky, Vidal-Puig, Wenk   +41 more
core   +1 more source

Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain

Journal of Lipid Research, 2008
Anandamide is an endogenous signaling lipid that binds to and activates cannabinoid receptors in the brain and peripheral tissues. The endogenous precursors of ananda­mide, N-arachidonoyl phosphatidylethanolamines (NArPEs), are a family of complex ...
Giuseppe Astarita, Faizy Ahmed, Daniele Piomelli   +2 more
doaj   +1 more source