Results 1 to 10 of about 8,364 (275)

Schisandra lignans ameliorate nonalcoholic steatohepatitis by regulating aberrant metabolism of phosphatidylethanolamines [PDF]

Acta Pharmaceutica Sinica B, 2023
Nonalcoholic steatohepatitis (NASH) is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder. Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NASH, while the other lipids ...
Lijuan Xue, Keanqi Liu, Caixia Yan, Junling Dun, Yexin Xu, Linlin Wu, Huizhu Yang, Huafang Liu, Lin Xie, Guangji Wang, Yan Liang   +10 more
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Lipidomics of polarized macrophages in the human adipose tissue [PDF]

Scientific Reports
Macrophages are critical components of the innate immune system that adapt their function based on local microenvironmental cues. In adipose tissue, macrophage polarization is intimately linked to metabolic regulation and inflammation.
Vladimír Vrkoslav, Kateřina Pražáková, Štěpán Strnad, Karel Paukner, Barbora Muffová, Soňa Kauerová, Jiří Froněk, David Sýkora, Josef Cvačka, Rudolf Poledne, Marek Petráš, Ivana Králová Lesná   +11 more
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Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition [PDF]

Physiological Reports
Pheochromocytoma and paraganglioma with a succinate dehydrogenase B subunit (SDHB) pathogenic variant are associated with a significant chance for metastasis.
Abdel A. Alli, Niharika Bala, Yiling Xu, Nancy D. Denslow, Hans K. Ghayee   +4 more
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Exploring preconception signatures of metabolites in mothers with gestational diabetes mellitus using a non-targeted approach [PDF]

BMC Medicine, 2023
Background Metabolomic changes during pregnancy have been suggested to underlie the etiology of gestational diabetes mellitus (GDM). However, research on metabolites during preconception is lacking.
Ling-Jun Li, Ximeng Wang, Yap Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Johan G. Eriksson, Zhongwei Huang, Mohammad L. Rahman, Liang Cui, Cuilin Zhang   +9 more
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Beyond bile acids synthesis: metabolomics profiling highlights extensive metabolic dysregulation and treatment response in CTX [PDF]

Orphanet Journal of Rare Diseases
Background Cerebrotendinous xanthomatosis (CTX) is an inherited metabolic disorder caused by variants in CYP27A1 leading to loss of sterol-27-hydroxylase activity.
Monte A. Del Monte, Jennifer Hanson, Penelope E. Bonnen   +2 more
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A Multi-Omics Approach Uncovers Divergent Mechanisms of Asthma in Normal Weight and Obese Children [PDF]

Metabolites
Background: Children with obesity-related asthma exhibit poorer symptom control and more frequent exacerbations than their normal-weight peers, but the underlying metabolic mechanisms are unclear.
Ilhame Diboun, Harshita Shailesh, Shana Jacob, Mohamed A. Elrayess, Stefan Worgall, Younes Mokrab, Ibrahim Janahi   +6 more
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Study on dynamic alterations of plasma lipid profiles during disease progression in combined allergic rhinitis and asthma syndrome based on lipidomics [PDF]

Frontiers in Immunology
Combined allergic rhinitis and asthma syndrome (CARAS) involves complex interactions between inflammation and lipid metabolism. This study recruited 90 CARAS patients admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from ...
Yanmin Shi, Yanmin Shi, Yanmin Shi, Yiting Li, Zifan Cheng, JiaJia Wang, JiaJia Wang, JiaJia Wang, Suyun Li, Suyun Li, Suyun Li, Yang Xie, Yang Xie, Yang Xie   +13 more
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Long-chain polyunsaturated fatty acid lipid and oxylipin alterations in postoperative delirium after cardiac surgery [PDF]

Journal of Lipid Research
Lipids play a crucial role in signaling, membrane dynamics, and inflammatory regulation, yet their involvement in postoperative delirium pathogenesis remains unclear.
Kwame Wiredu, Pruthvi Gowda, James Rhee, Ariel Mueller, Christopher Simon, Occam Kelly Graves, Jason Zhensheng Qu, Matthew Spite, Tina B. McKay, Oluwaseun Akeju   +9 more
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Lipidomic profiling of the cerebrospinal fluid in moyamoya angiopathy patients [PDF]

Orphanet Journal of Rare Diseases
Background Moyamoya angiopathy (MA) is a rare cerebrovascular disorder which can occur in both children and young adults, characterized by progressive occlusion of the intracranial carotid arteries, leading patients to ischemic and haemorrhagic strokes ...
Antonella Potenza, Gemma Gorla, Tatiana Carrozzini, Giuliana Pollaci, Michele Dei Cas, Francesco Acerbi, Ignazio G. Vetrano, Paolo Ferroli, Isabella Canavero, Rita Paroni, Nicola Rifino, Anna Bersano, Laura Gatti   +12 more
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Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice

Biomedicines, 2022
Traumatic brain injury (TBI) is often complicated by long-lasting disabilities, including headache, fatigue, insomnia, hyperactivity, and cognitive deficits.
Lisa Hahnefeld, Alexandra Vogel, Robert Gurke, Gerd Geisslinger, Michael K. E. Schäfer, Irmgard Tegeder   +5 more
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