Results 51 to 60 of about 1,479 (250)

Melittin interaction with sulfated sugars and cell membranes [PDF]

, 2008
The presented work focused on an alternative mechanism of action of melittin on the cell membranes. The study using ITC reveals that melittin has a high affinity for several glycosaminoglycans (GAGs), i.e.
Klocek, Gabriela
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Lipidomics of polarized macrophages in the human adipose tissue

Scientific Reports
Macrophages are critical components of the innate immune system that adapt their function based on local microenvironmental cues. In adipose tissue, macrophage polarization is intimately linked to metabolic regulation and inflammation.
Vladimír Vrkoslav, Kateřina Pražáková, Štěpán Strnad, Karel Paukner, Barbora Muffová, Soňa Kauerová, Jiří Froněk, David Sýkora, Josef Cvačka, Rudolf Poledne, Marek Petráš, Ivana Králová Lesná   +11 more
doaj   +1 more source

PEBP1 Wardens Ferroptosis by Enabling 15LO Generation of Death Signals, 15-Hydroperoxy-Phosphatidylethanolamines. Wenzel et al.

, 2017
MALDI-MS imaging raw data for Supplemental Figures of Wenzel et al, "PEBP1 Wardens Ferroptosis by Enabling 15LO Generation of Death Signals, 15-Hydroperoxy-Phosphatidylethanolamines." The data is readable with Bruker Daltonics FlexImaging software (www ...
Sparvero, L (via Mendeley Data)
core   +1 more source

N-acyl phosphatidylethanolamines affect the lateral distribution of cholesterol in membranes [PDF]

, 2005
N-Acyl phosphatidylethanolamines are negatively charged phospholipids, which are naturally occurring albeit at low abundance. In this study, we have examined how the amide-linked acyl chain affected the membrane behavior of the N-acyl-1-palmitoyl-2 ...
Slotte, J. Peter, Térová, Bohdana, Térová, B., Slotte, J.P., Hansen, Harald S., Petersen, G., Petersen, Gitte   +6 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Elastic Properties of Polyunsaturated Phosphatidylethanolamines Influence Rhodopsin Function

, 2013
Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (M(II)), the photointermediate of bovine rhodopsin that activates the G protein transducin.
Teague, Walter E., Jr., Gawrisch, Klaus, Soubias, Olivier, Rand, R. Peter, Petrache, Horia, Fuller, Nola, Hines, Kirk G.   +6 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε [PDF]

, 2019
香川大学Kagawa University博士（医学）N-Acyl-phosphatidylethanolamines (NAPEs) represent a class of glycerophospholipids and serve as the precursors of bioactive N-acylethanolamines, including arachidonoylethanolamide (anandamide), palmitoylethanolamide and ...
Binte Mustafiz, Smriti Sultana, ビンテ ムスタフィズ, スリーテイ スルタナ   +1 more
core   +2 more sources

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source