Results 61 to 70 of about 35,571 (360)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

Redox Biology, 2023
Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH), but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III clinical trial. Using a prolonged western diet-feeding murine NASH model,
Aoxiang Zhuge, Shengjie Li, Yin Yuan, Shengyi Han, Jiafeng Xia, Qiangqiang Wang, Shuting Wang, Pengcheng Lou, Bo Li, Lanjuan Li   +9 more
doaj   +1 more source

Fluctuations in mixtures of lamellar- and nonlamellar-forming lipids

, 2000
We consider the role of nonlamellar-forming lipids in biological membranes by examining fluctuations, within the random phase approximation, of a model mixture of two lipids, one of which forms lamellar phases while the other forms inverted hexagonal ...
M. Schick, Markin V. S., Xiao-jun Li
core   +1 more source

Clinical relevance of biomarkers of oxidative stress [PDF]

, 2015
SIGNIFICANCE Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation ...
Ana Cipak Gasparovic, Annie R. Knight, Antonio Cuadrado, Awad JA, Baker JR, Broedbaek K, Daniela Weber, David Cheng, Emma Louise Taylor, Harald H.H.W. Schmidt, Henrik Enghusen Poulsen, Herzenberg LA, Holvoet P, Jeannette Oettrich, Jeroen Frijhoff, Ji L, Johnson D, Kaplowitz N, Khan J, McCord JM, Miyata T, Neven Zarkovic, Paul G. Winyard, Pietro Ghezzi, Poulsen HE, Roland Stocker, Salomon RG, Sean S. Davies, Takahashi M, Tatjana Ruskovska, Tilman Grune, WHO, Witko-Sarsat V   +32 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine[S]

Journal of Lipid Research, 2013
Among amphitropic proteins, human glycolipid transfer protein (GLTP) forms a structurally-unique fold that translocates on/off membranes to specifically transfer glycolipids.
Xiuhong Zhai, William E. Momsen, Dmitry A. Malakhov, Ivan A. Boldyrev, Maureen M. Momsen, Julian G. Molotkovsky, Howard L. Brockman, Rhoderick E. Brown   +7 more
doaj   +1 more source

Bioprospecting Bioactive Polar Lipids from Olive (Olea europaea cv. Galega vulgar) Fruit Seeds: LC-HR-MS/MS Fingerprinting and Sub-Geographic Comparison

Foods, 2022
Olive seeds have been considered as a new nutritionally healthy food supplement. They are rich in monounsaturated n-9 and essential polyunsaturated n-6 lipids. However, little is known about their polar lipids, potentially bioactive and chemical identity
Eliana Alves, Felisa Rey, Tânia Melo, Madalena P. Barros, Pedro Domingues, Rosário Domingues   +5 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Toy amphiphiles on the computer: What can we learn from generic models?

, 2009
Generic coarse-grained models are designed such that they are (i) simple and (ii) computationally efficient. They do not aim at representing particular materials, but classes of materials, hence they can offer insight into universal properties of these ...
Bernardes, Bhattacharya, Brannigan, Brannigan, Brannigan, Brannigan, Carmesin, Cooke, Cordomi, de Meyer, de Planque, de Vries, de Vries, Doi, Düchs, Düchs, Farago, Fraaije, Fraaije, Fraser, Fredrickson, Fredrickson, Ganesan, Gennis, Gompper, Grest, Gunn, Guo, Guo, Guo, Guo, Götz, Haas, Haas, Haas, Halley, Harroun, He, He, He, He, Helfand, Helfand, Helfrich, Huang, Israelachvili, Izvekov, Jain, Karaborni, Katsaras, Killian, Komura, Koynova, Koynova, Kranenburg, Kranenburg, Kranenburg, Larson, Larson, Lei, Lenz, Lenz, Li, Lindahl, Linhananta, Loison, Loison, Loison, Marrink, Marsh, Matsen, Matsen, Matsen, Maurits, Maurits, Müller, Müller, Müller-Plathe, Noguchi, Noguchi, Pabst, Pochan, Safran, Schmid, Schmid, Schmid, Schmid, Schmid, Schmid, Schmid, Schmidt, Sengupta, Sevink, Sevink, Sharpe, Shen, Shillcock, Shillcock, Shull, Shull, Smit, Smit, Smith, Soddemann, Soddemann, Stadler, Stadler, Sun, Tardieu, Tenchov, Varandas, Venturoli, Venturoli, von Gottberg, von Gottberg, Wang, Werner, Werner, Werner, West, Wheeler, Whitmore, Yamamoto, Zhang, Zhang   +124 more
core   +1 more source

Phosphatidylethanolamines Modified by γ-Ketoaldehyde (γKA) Induce Endoplasmic Reticulum Stress and Endothelial Activation*

Journal of Biological Chemistry, 2011
Peroxidation of plasma lipoproteins has been implicated in the endothelial cell activation and monocyte adhesion that initiate atherosclerosis, but the exact mechanisms underlying this activation remain unclear.
Lilu Guo, Zhongyi Chen, B. Cox, V. Amarnath, R. Epand, R. Epand, S. Davies   +6 more
semanticscholar   +1 more source