Results 91 to 100 of about 18,384,661 (291)

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, EarlyView.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD

Respiratory Research
Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition. Given patients with COPD continue to experience exacerbations despite the availability of effective therapies, anti-inflammatory treatments targeting novel ...
Mirco Govoni, Michele Bassi, Luca Girardello, Germano Lucci, François Rony, Rémi Charretier, Dmitry Galkin, Maria Laura Faietti, Barbara Pioselli, Gloria Modafferi, Rui Benfeitas, Martina Bonatti, Daniela Miglietta, Jonathan Clark, Frauke Pedersen, Anne-Marie Kirsten, Kai-Michael Beeh, Oliver Kornmann, Stephanie Korn, Andrea Ludwig-Sengpiel, Henrik Watz   +20 more
doaj   +1 more source

Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta [PDF]

, 2008
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biological functions in every cell type by generating lipid second messengers.
Nock, G.
core  

Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. [PDF]

, 2013
The four mammalian phosphatidylinositol 4-kinases modulate inter-organelle lipid trafficking, phosphoinositide signalling and intracellular vesicle trafficking. In addition to catalytic domains required for the synthesis of PI4P, the phosphatidylinositol
Waugh, MG, Minogue, S, Minogue, Shane, Clayton, EL, Clayton, Emma L., Waugh, Mark G.   +5 more
core   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

PI3k Inhibitors in NHL and CLL: An Unfulfilled Promise

Blood and Lymphatic Cancer: Targets and Therapy, 2023
Naji Bou Zeid,1 Victor Yazbeck2 1Hôtel-Dieu de France Hospital, Saint Joseph University of Beirut, Beirut, Lebanon; 2Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USACorrespondence: Victor Yazbeck, Virginia Commonwealth University,
Bou Zeid N, Yazbeck V
doaj  

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Multi-Method Investigation of the Role of the PI3K/Akt Pathway in Sinomenine-Mediated Neuroprotection Against Acute Ischemic Stroke

Frontiers in Bioscience-Landmark
Background:Effective neuroprotective therapies for acute ischemic stroke (AIS) remain limited due to the complex interplay between neuroinflammation and apoptosis.
Xinzuo Qin, Wancheng Zheng, Xiaoqun Li, Yun Du, Lulu Wen, Miao Qu   +5 more
doaj   +1 more source

Evolution of PIKK family kinase inhibitors: A new age cancer therapeutics

Frontiers in Bioscience-Landmark, 2020
Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, chromosome maintenance, DNA ...
Althaf Shaik, Sivapriya Kirubakaran
doaj   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source