Results 131 to 140 of about 73,691 (318)

Synthesis of anti-tumour phosphatidylinositol analogues from glucose by the use of ring-closing olefin metathesis [PDF]

, 2004
A divergent strategy is described for synthesis of the novel phosphatidylinositols 1-3. The synthetic approach commences from benzyl-protected methyl 6-iodo-6-deoxy-a-D-glucopyranoside, which undergoes zinc-mediated reductive fragmentation followed by ...
Madsen, Robert, Andresen, Thomas Lars, Skytte, Dorthe M.   +2 more
core  

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Lipid cartography of atherosclerotic plaque by cluster-TOF-SIMS imaging [PDF]

, 2007
Several frozen vessels bearing atherosclerotic lesion were analysed by cluster TOF-SIMS (time-of-flight secondary ion mass spectrometry) to map their lipid (fatty acids, cholesterol, vitamin E, phosphatidic acids, phosphatidylinositols and ...
Vivanco, Fernando, Brunelle, Alain, Aragoncillo, Paloma, Touboul, David, Laprévote, Olivier, Egido, Jesús, Mas, Sebastian   +6 more
core   +1 more source

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.

Journal of Hepatology, 2016
P. Luukkonen, You Zhou, T. Hyötyläinen, M. Leivonen, J. Arola, M. Orho-Melander, M. Orešič, H. Yki-Järvinen   +7 more
semanticscholar   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Lipides polaires et protéines dans les membranes des globules gras du lait en tant qu'acteurs de la lipolyse spontanée dans le lait de vache [PDF]

International audienceA study of the lipidome and proteome was performed on milk fat globule membranes (MFGM) originating from milk samples from high (HL) and low (LL) lipolysis groups of cows.
Viala, Didier, Bernard, Laurence, Delosière, Mylène, Imbert, Alyssa, Bonnet, Muriel, Cebo, Christelle, Hurtaud, Catherine   +6 more
core   +1 more source

Lipidomic Profiling of Dechorionated Fertilized Eggs and Egg Chorion in Three Tropical Marine Fish Species: Insights into Reproductive Physiology and Nutrition

Biology
Broodstock nutrition is a key determinant of reproductive output in marine fishes because lipids support yolk formation, embryonic development, and early larval viability.
Yi-Hong Liu, Hua-Yang Guo, Bao-Suo Liu, Teng-Fei Zhu, Lin Xian, Nan Zhang, Ke-Cheng Zhu, Jian-She Zhang, Dian-Chang Zhang   +8 more
doaj   +1 more source

Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression

Arthritis &Rheumatology, EarlyView.
Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Enrichment of phosphatidylinositols with specific acyl chains.

Biochimica et Biophysica Acta, 2014
Kenneth D'souza, R. Epand
semanticscholar   +1 more source