Results 261 to 270 of about 10,007 (332)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health. [PDF]

J Intern Med
Maioli S, Nalvarte I, Ankarcrona M, Schultzberg M, Zuloaga KL, Goikolea J, Visser PJ, De Strooper B, Winblad B, Pizzo P, Williams PA, Rodriguez-Rodriguez P, Naia L.   +12 more
europepmc   +1 more source

SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry

Puspangana Singh, Purba Pahari, Srija Mukherjee, Sharmistha Karmakar, Markus Hoffmann, Taraknath Mandal, Dibyendu Kumar Das   +6 more
openalex   +1 more source

Reconstitution of phosphatidylserine import into rat liver mitochondria

, 1989
Dennis R. Voelker
openalex   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity. [PDF]

Physiol Res
Alharthy FH, Alsughayyir J, Alfhili MA.
europepmc   +1 more source

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

, 2010
Baohui Chen, Yue Jiang, Sheng Zeng, Jiacong Yan, Xin Li, Yan Zhang, Wei Zou, Xiaochen Wang   +7 more
openalex   +2 more sources

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The synthesized bioresorbable bone wax material for hemostasis and osteogenesis. The preparation process of the novel resorbable bone wax and its mechanism of accelerating coagulation and promoting osteoregeneration through blood cell aggregation. Abstract Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at ...
Longbao Feng, Yanbin Lu, Pengyu Fu, Shaojun Li, Pengning She, Yang xiao, Jiaming Ye, Wanqi Li, Shaochuan Li, Wei Xue, Rui Guo   +10 more
wiley   +1 more source

<i>sn</i>-Position-Resolved Quantification of Aminophospholipids by Isotopic <i>N</i>,<i>N</i>-Dimethyl Leucine Labeling and High-Resolution Ion Mobility Mass Spectrometry. [PDF]

Anal Chem
Xu S, Zhu Z, Gu TJ, Wang Z, Delafield DG, Rigby MJ, Lu G, Ma M, Liu PK, Puglielli L, Li L.   +10 more
europepmc   +1 more source