Results 271 to 280 of about 10,007 (332)

Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 1, Page 26-40, January 2026.
ABSTRACT The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...
Claire Auditeau, Aurélie Fricot, Raphaël Gauthier, Abdoulaye Sissoko, Zeynep Cacan, Céline Gounou, Laure Joseph, Sandra Manceau, Slimane Allali, Michael Dussiot, Mickael Marin, Alexis Lavergne, Mariem Khamari, Sophie Moog, Elsa Bianchini, Laetitia Claer, Sandrine Laurance, Valentine Brousse, Sébastien Eymieux, Philippe Roingeard, Pascal Amireault, Thiago Trovati Maciel, Alain Brisson, Pierre Buffet, François Saller, Delphine Borgel, Camille Roussel   +26 more
wiley   +1 more source

Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats. [PDF]

Acta Physiol (Oxf)
Arora S, Houdek P, Čajka T, Dočkal T, Sládek M, Sumová A.   +5 more
europepmc   +1 more source

Selection of Host Plasma Membrane Lipids by HIV‐1 Gag Protein

BioEssays, Volume 48, Issue 1, January 2026.
Enrichment of sphingomyelin in the HIV‐1 envelope arises from Gag binding to PI(4,5)P2, which triggers reorganization of plasma membrane sphingomyelin/cholesterol domains through unknown mechanisms. We propose that cholesterol‐mediated interleaflet coupling between sphingomyelin and PI(4,5)P2, rather than interdigitation, underlies Gag‐induced lipid ...
Nario Tomishige, Yves Mély, Toshihide Kobayashi   +2 more
wiley   +1 more source

Phosphatidylserine Externalization in Cancer: Biology, Immune Suppression, and Emerging Theragnostic Strategies [PDF]

Maro Yoo, K. D. Kim
openalex   +1 more source

Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Cytotoxic effects exhibited by OSPI against A549 cells significantly reduced the cell viability. Elevated caspase levels induced by OSPI in Hep‐G2 cells suggest intrinsic and extrinsic apoptosis. Treatment with OSPI and DOF exhibited elevated p53 expression in A549 cells, suggesting p53‐mediated apoptosis.
Letisha Maistry, Abe Shegro Gerrano, John J. Mellem   +2 more
wiley   +1 more source

Targeting PIEZO1-TMEM16F Coupling to Mitigate Sickle Cell Disease Complications. [PDF]

Am J Hematol
Liang P, Wan YS, Shan KZ, Chou R, Zhang Y, Delahunty M, Khandelwal S, Francis SJ, Arepally GM, Telen MJ, Yang H.   +10 more
europepmc   +1 more source

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

Membrane Composition Modulates Vp54 Binding: A Combined Experimental and Computational Study. [PDF]

Pathogens
Guo W, Dong R, Okedigba AO, Sanchez JE, Agarkova IV, Abisamra EM, Jelinsky A, Riekhof W, Noor L, Dunigan DD, Van Etten JL, Capelluto DGS, Xiao C, Li L.   +13 more
europepmc   +1 more source

Engineering Liposomes for Neurodegenerative Diseases: Targeted Delivery and Regenerative Potential

ChemNanoMat, Volume 12, Issue 1, January 2026.
Liposomal nanocarriers offer therapeutic promise for neurodegenerative diseases by encapsulating diverse agents such as neurotrophic factors and mRNA while targeting the blood‐brain barrier. Designed to stimulate neuronal repair and restore function, these lipid vesicles advance strategies for optimized design and central nervous system delivery ...
Oybek Ashirov, Shakhnoz Azimova, Borislav Angelov, Angelina Angelova   +3 more
wiley   +1 more source

Thrombocytopenia in patients with Plasmodium vivax in Colombia is associated with anti-phosphatidylserine autoantibodies and IL-6, IFNγ, IL-10 and TGF-β. [PDF]

PLoS Negl Trop Dis
Velasco-Pareja MC, Tovar-Acero C, Cantero Guevara ME, Rodriguez A, Rivera-Correa J, Yasnot-Acosta MF.   +5 more
europepmc   +1 more source