Results 111 to 120 of about 90,252 (235)

Phosphine-Catalyzed (3 + 2) Annulation of δ‑Acetoxy Allenoates with 2‑Sulfonamidomalonate: Synthesis of Highly Substituted 3‑Pyrrolines and Mechanistic Insight

, 2018
A mild and efficient synthetic protocol for 3-pyrrolines via the phosphine-catalyzed (3 + 2) annulation of δ-acetoxy allenoates with 2-sulfonamidomalonate is reported. The asymmetric version (up to 83% ee) is also achieved by using phosphine (R)-SITCP as
Dong Wang (73290), Xiaofeng Tong (1490881), Yang Hong (124259), Wei Liu (20030)   +3 more
core   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Modeling the Efficacy of Phosphine on Eggs of Major Stored-Product Insect Species: Investigating Strains with Varying Susceptibility Levels

Agriculture
Phosphine is a widely utilized fumigant insecticide in stored-product facilities; however, its excessive application and improper usage have contributed to the emergence of resistance in insect populations.
Marina Gourgouta, Maria K. Sakka, Evmorfia P. Bataka, M. Carolin Götze, Christos T. Nakas, Christos G. Athanassiou   +5 more
doaj   +1 more source

Phosphine-Catalyzed Divergent [4+3] Domino Annulations of CF₃‑Containing Imines with MBH Carbonates: Construction of Perfluoroalkylated Benzazepines

, 2019
Phosphine-catalyzed divergent [4+3] domino annulations of fluorinated imidoyl chlorides with MBH carbonates were developed. Two classes of perfluoroalkylated benzazepines were obtained in moderate to good yields via an interesting dearomatization ...
Junlong Chen (4484776), You Huang (44838), Zhongmo Yin (7299563)   +2 more
core   +1 more source

An Unbiased Geometry‐Resolved Membrane Platform for Proteome‐Scale Discovery of Membrane Curvature Sensors

Advanced Science, EarlyView.
A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa, Rikuto Kawakami, Kunanon Chattrairat, Tatsuya Niwa, Taiga Ajiri, Takao Yasui, Masayoshi Tanaka   +6 more
wiley   +1 more source

Engineering Carbon Cloth‐Catalyst Interfaces for Pt‐Free Hydrogen Evolution Across the Full pH Spectrum

Advanced Science, EarlyView.
Interfacial synergy between carbon cloth and Pt‐free metal/nonmetal catalysts enhances charge transfer, wettability, active site accessibility, and hydrogen bubble release, enabling efficient and durable hydrogen evolution across acidic, neutral, and alkaline media for scalable green hydrogen production.
Syed Mohammed Hubaish, Belal Salah, Khouloud Jlassi, Ali A. Abdelhafiz, Kamel Eid   +4 more
wiley   +1 more source

Volatile Additives Engineering: A Trustworthy Morphology Control Strategy in Non‐Fullerene Organic Solar Cells

Advanced Science, EarlyView.
In this review, the classification and development history of the volatile solid and solvent additives are comprehensively summarized, the underlying mechanisms of morphology optimization are discussed, and a summary of volatile additive‐induced improvements in interfacial layer performance is provided.
Jianqiang Qin, Zhiqin Lai, Jiang‐Ling Shi, Zheng Xiao, Yuwei Duan, Zhiping Hu, Juan Du, Qiang Peng   +7 more
wiley   +1 more source

Transition from Kwon [4+2]- to [3+2]-cycloaddition enabled by AgF-assisted phosphine catalysis

Nature Communications
Phosphine catalysis generally relies on the potential of carbanion-phosphonium zwitterions that are generated via nucleophilic addition of phosphine catalyst to electrophilic reactants.
Jinlong Qian, Lijin Zhou, Yuyi Wang, Xiaoyu Zhou, Xiaofeng Tong   +4 more
doaj   +1 more source

Resistance of Stored Grain Pests to Phosphine and Its Integrated Management Strateg

Liang you shipin ke-ji
The fumigant has been approved by the World Health Organization for use in grain storage, targeting the eradication of pests in areas where grain is stored or transported to reduce insect and mold activities, thereby minimizing storage losses.
ZHANG Hui-yan, CHEN Xin, ZHANG Hong-qing, LI Yan-yu, TIAN Xiao-wei, ZHOU Gui-ming, TAO Hai-hua, GONG Jian-min   +7 more
doaj   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source