Plasma nicotinamide adenine dinucleotide pathway depletion is linked to diastolic dysfunction in patients with advanced chronic liver disease. [PDF]
Gill M +10 more
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Acute neuromuscular fatigue in circuit strength training: effects of varying work-to-rest durations. [PDF]
Agudo-Ortega A +5 more
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Ultra-high field <sup>31</sup>P functional magnetic resonance spectroscopy reveals NAD<sup>+</sup> dynamics in brain energy metabolism during visual stimulation. [PDF]
Kaiser A +8 more
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Skeletal muscle energetics during submaximal contractions are linked to metabolic performance during ambulatory exercise: A pilot study in male adults. [PDF]
Hayden CMT +5 more
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Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine [PDF]
Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes1-3. Recent data have indicated that thermogenic fat cells use creatine to stimulate futile substrate cycling, dissipating chemical energy as heat4,5.
Yizhi Sun, Janane F Rahbani, Bo Hu
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On the mechanisms of neuroprotection by creatine and phosphocreatine [PDF]
Nickolay Brustovetsky, Janet Dubinsky
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A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs
Medicinal Chemistry, 2018Adenosine triphosphate (ATP) is the energy currency of the body; it takes part in various and indispensable metabolic processes for the maintenance of cell homeostasis, degrading to its hydrolysis product, adenosine diphosphate (ADP). Efficient ways to restore ATP are therefore necessary in the cells.
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IT is generally assumed that when phosphocreatine is hydrolysed either enzymatically or spontaneously, the end products are creatine and phosphoric acid. This, however, is not always found to be the case. When phosphocreatine is hydrolysed at 38° in saturated picric acid, about 10 percent of the substance is converted into creatinine (Fig. 1.).
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