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Simultaneous creatine and phosphocreatine mapping of skeletal muscle by CEST MRI at 3T
Magnetic Resonance in Medicine, 2023To confirm that CrCEST in muscle exhibits a slow‐exchanging process, and to obtain high‐resolution amide, creatine (Cr), and phosphocreatine (PCr) maps of skeletal muscle using a POlynomial and Lorentzian Line‐shape Fitting (PLOF) CEST at 3T.
Licheng Ju +8 more
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A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs
Medicinal Chemistry, 2018Adenosine triphosphate (ATP) is the energy currency of the body; it takes part in various and indispensable metabolic processes for the maintenance of cell homeostasis, degrading to its hydrolysis product, adenosine diphosphate (ADP). Efficient ways to restore ATP are therefore necessary in the cells.
Arkel, Maria +8 more
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A model for phosphocreatine resynthesis
Journal of Applied Physiology, 1997Nevill, Alan M., David A. Jones, David McIntyre, Gregory C. Bogdanis, and Mary E. Nevill. A model for phosphocreatine resynthesis. J. Appl. Physiol. 82(1): 329–335, 1997.—A model for phosphocreatine (PCr) resynthesis is proposed based on a simple electric circuit, where the PCr store in muscle is likened to the stored charge on the capacitor.
A M, Nevill +4 more
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The identification of phosphocreatine in liver
Biochimica et Biophysica Acta, 1951Abstract 1. 1. The nature of the acid-molybdate-labile P compound occurring in trichloracetic acid extracts of livers from guinea pigs treated with carbon tetrachloride has been investigated. 2. 2. On the basis of the P:creatine ratio, the neture and determination of the compounds liberated in the presence of acid-molybdate, and the behaviour
H, BARKER, A H, ENNOR
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Nature, 1947
IT is generally assumed that when phosphocreatine is hydrolysed either enzymatically or spontaneously, the end products are creatine and phosphoric acid. This, however, is not always found to be the case. When phosphocreatine is hydrolysed at 38° in saturated picric acid, about 10 percent of the substance is converted into creatinine (Fig. 1.).
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IT is generally assumed that when phosphocreatine is hydrolysed either enzymatically or spontaneously, the end products are creatine and phosphoric acid. This, however, is not always found to be the case. When phosphocreatine is hydrolysed at 38° in saturated picric acid, about 10 percent of the substance is converted into creatinine (Fig. 1.).
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Amelioration of renal ischemic injury by phosphocreatine
Journal of Surgical Research, 1991Phosphocreatine (PCr) is a critical intracellular energy reservoir used in the regeneration of ATP. The aim of this study was to determine the efficacy of exogenously added PCr on preservation of renal function in an in vitro model. The renal artery and ureter of a rat were cannulated and the kidney was subjected to 45 min of normothermic in vivo ...
R, Rodriguez +4 more
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Phosphocreatine resynthesis is not affected by creatine loading
Medicine & Science in Sports & Exercise, 1999Oral creatine supplementation has been shown to improve power output during high intensity intermittent muscle contractions. Facilitated muscle phosphocreatine (PCr) resynthesis, by virtue of elevated intracellular PCr concentration, might contribute to this ergogenic action. Therefore, the effect of creatine loading (C: 25 g X d(-1) for 5 d) on muscle
K, Vandenberghe +4 more
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Absence of detectable phosphocreatine in rat luteal cells
American Journal of Physiology-Endocrinology and Metabolism, 1987Previous studies from this laboratory showed that adenosine amplifies the action of luteinizing hormone (LH) severalfold in rat and human luteal cells by an intracellular, adenosine 5'-triphosphate (ATP)-linked process. The objective of this study was to evaluate the contribution of phosphocreatine (PCr) and creatine kinase (CK) to the dynamics of ...
J C, Cross +3 more
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2007
The invention relates to novel phosphocreatine complexes useful for the treatment of diseases of the central nervous system, having the following general formula (I): wherein M is a metal, preferably Mg, and An- is an organic or inorganic anion. The pharmaceutically acceptable salts of such complexes also fall within the scope of the invention.
BALESTRINO, MAURIZIO +4 more
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The invention relates to novel phosphocreatine complexes useful for the treatment of diseases of the central nervous system, having the following general formula (I): wherein M is a metal, preferably Mg, and An- is an organic or inorganic anion. The pharmaceutically acceptable salts of such complexes also fall within the scope of the invention.
BALESTRINO, MAURIZIO +4 more
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Clinical applications of phosphocreatine and related mechanisms
Life SciencesPhosphocreatine (PCr), a naturally occurring creatine phosphorylated molecule, is a high-energy phosphate compound that is one of the most important substances involved in cell energy metabolism, and also has anti-apoptosis and anti-oxidative stress effects.
Jing, Wang +4 more
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