Results 121 to 130 of about 161,329 (309)

Potential Roles of PDE4 Inhibitors in Peptic Ulcer Treatment

Клинический разбор в общей медицине
Introduction. Peptic ulcer disease, a common gastrointestinal disorder, is mostly caused by Helicobacter pylori infection, non-steroidal anti-inflammatory drug usage, and lifestyle factors including alcohol use and smoking.
Khaled A. Abdel-Sater
doaj   +1 more source

The place of a phosphodiesterase 4 inhibitor in the treatment strategy for psoriatic arthritis

Современная ревматология, 2018
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the  locomotor system and leads to the development of ...
V. I. Mazurov, E. A. Trofimov, I. Z. Gaydukova   +2 more
doaj   +1 more source

The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study [PDF]

, 2010
The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat ...
Eweka, A, Eweka, AO
core   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Dysregulated biosynthesis and hydrolysis of cyclic-di-adenosine monophosphate impedes sporulation and butanol and acetone production in Clostridium beijerinckii NCIMB 8052

Frontiers in Bioengineering and Biotechnology
IntroductionAlthough solventogenic Clostridium species (SCS) produce butanol, achieving high enough titers to warrant commercialization of biobutanol remains elusive. Thus, deepening our understanding of the intricate cellular wiring of SCS is crucial to
Marian M. Awaga-Cromwell, Santosh Kumar, Hieu M. Truong, Eric Agyeman-Duah, Christopher C. Okonkwo, Victor C. Ujor   +5 more
doaj   +1 more source

Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. [PDF]

, 2018
Macrophage migration is an essential step in host defense against infection and wound healing. Elevation of cAMP by inhibiting phosphodiesterase 4 (PDE4), enzymes that specifically degrade cAMP, is known to suppress various inflammatory responses in ...
Catherine Jin, S-L, Chuang, Tsung-Hsien, Conti, Marco, Ding, Shiau-Li, Hsiung, Te-Chih, Weng, Fu-Chun, Wu, Chin-Pyng, Yang, Jing-Xing   +7 more
core  

Nerandomilast and the Evolving Therapeutic Paradigm in Pulmonary Fibrosis: From Mechanism to Clinical Efficacy

iNew Medicine, EarlyView.
Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai, Jia Deng, Hongquan Wang, Yao Yao, Tao Wang   +4 more
wiley   +1 more source

Magnetocardiography combined with machine learning for pulmonary hypertension detection and improved short‐term risk assessment

Interdisciplinary Medicine, EarlyView.
Magnetocardiography (MCG) enables non‐invasive mapping of cardiac magnetic fields. In this study, an MCG‐based machine learning model detects pulmonary hypertension with robust performance. Furthermore, MCG features may improve the accuracy of short‐term risk assessment.
Yuankun Qi, Jiaqi Liang, Kai Ma, Xiaoyu Hu, Yu Zhang, Xiaole Han, Dong Xu, Xu Zhang, Xiaopei Cui, Min Xiang, Hongyu Zhang, Jiancheng Fang   +11 more
wiley   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Patient Characteristics, Disease Profile and Treatment Patterns in Mild and Moderate Psoriasis Patients: Results From Real‐World Clinical Practices in Five European Countries (PROSPECT Study)

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Categorisation of psoriasis (PsO) disease severity in patients varies, although body surface area (BSA) affected is commonly used (< 3% ‘mild’, 3%–10% ‘moderate’ and > 10% ‘severe’). While moderate‐severe PsO has been well‐studied, more limited information regarding mild‐to‐moderate PsO is available.
Emily Goddard, Aaron Keal, James Hetherington, Sophie Barlow, David Wu, Melany Worbes‐Cerezo, Alexander Litvintchouk   +6 more
wiley   +1 more source