Results 121 to 130 of about 89,654 (264)

Summary of Research: Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease: Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Trials (the ENHANCE Trials). [PDF]

Adv Ther
Anzueto A, Barjaktarevic IZ, Siler TM, Rheault T, Rickard K, O'Donovan K, Sciurba F.   +6 more
europepmc   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Redox regulation of PDE6 and cGMP signaling in diabetic retinal neurodegeneration. [PDF]

Biochem Biophys Rep
Perez-Martinez CJ, Lewis-Luján LM, Cota-Arrayales CA, Guerrero-Magaña DE, Vargas-Durazo JT, Trushin MV, Osadchuk MA, Iloki-Lewis AP, Galvez-Ruiz JC, Iloki-Assanga SB.   +9 more
europepmc   +1 more source

Temporal Trends in Intracavernosal Injection Therapy and Penile Prosthesis Implantation in the Era of Phosphodiesterase‐5 Inhibitors for Erectile Dysfunction in Australia

ANZ Journal of Surgery, EarlyView.
ABSTRACT Introduction Phosphodiesterase‐5 inhibitors (PDE5‐Is) transformed erectile dysfunction (ED) management as first‐line therapy; nonetheless, many patients require second‐ and third‐line options due to inadequate response, side effects, or contraindications.
Nicholas Gillman, Eric Chung
wiley   +1 more source

Phosphodiesterase 9 (PDE9) Inhibitors May Provide Effective Treatments for Neurodegenerative, Cardiovascular and Other Diseases. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

Function drives 1‐year decision regret in radical prostatectomy: a multicentre prospective study

BJU International, EarlyView.
Objectives To identify contemporary drivers of postoperative decision regret 1 year after radical prostatectomy (RP). Patients and Methods In this prospective, multicentre study, patients undergoing robot‐assisted RP (RARP) or retropubic open RP (ORP) for localised prostate cancer at seven centres in Germany and Austria (2022–2024) completed ...
Christopher Hirtsiefer, Emma Kümmel, Anna Vogelgesang, Fabian Falkenbach, Mona Kafka, Annemarie Uhlig, Tim Nestler, Cem Aksoy, Iva Simunovic, Johannes Huber, Isabel Heidegger, Markus Graefen, Marianne Leitsmann, Christian Thomas, Martin Baunacke   +14 more
wiley   +1 more source

Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8A. [PDF]

iScience
Papaioannou G, Sato T, Houghton C, Yan C, Kotsalidis PE, Strauss KE, Dean T, Mazur CM, Nelson AJ, Stokes MP, Gardella TJ, Wein MN.   +11 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Structural and biochemical insights into the inhibition of <i>Mycobacterium tuberculosis</i> cyclic dinucleotide phosphodiesterase by a sulfur-modified cyclic dinucleotide analog. [PDF]

RSC Chem Biol
Hanuman DS, Neeharika S, Murari SK, Yeboah SK, Sintim HO, Rajakumara E.   +5 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source