Results 151 to 160 of about 93,838 (303)

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

Association between beta-1-adrenoceptor blockade and risk of Raynaud's phenomenon: Mendelian randomisation study. [PDF]

J Scleroderma Relat Disord
Williams JC, Rogers K, Coulson K, Hughes DM, Hughes M, Zhao SS.   +5 more
europepmc   +1 more source

Relaxin‐2 improves type I diabetes mellitus‐induced erectile dysfunction in rats by protecting cavernous endothelial and smooth muscle function, and inhibiting penile fibrosis and apoptosis

Andrology, EarlyView.
Abstract Background Diabetes mellitus‐induced erectile dysfunction (DMED) responds poorly to first‐line treatments, necessitating the development of new therapeutic strategies. Relaxin‐2 (RLX‐2) plays a crucial role in protecting vascular endothelium, vasodilatation, and antifibrosis in various diseases.
Bocheng Tu, Kang Liu, Bo Wen, Peng Hu, Taotao Sun, Beining Li, Manan Sulaiman, Shujun Jiang, Tao Wang, Jihong Liu, Yang Luan   +10 more
wiley   +1 more source

The heart, a secondary organ in the control of blood circulation

Experimental Physiology, EarlyView., 2023
Abstract Circulation of the blood is a fundamental physiological function traditionally ascribed to the pressure‐generating function of the heart. However, over the past century the ‘cardiocentric’ view has been challenged by August Krogh, Ernst Starling, Arthur Guyton and others, based on haemodynamic data obtained from isolated heart preparations and
Branko Furst, José González‐Alonso
wiley   +1 more source

Molecular Approaches to Treating Chronic Obstructive Pulmonary Disease: Current Perspectives and Future Directions. [PDF]

Int J Mol Sci
Vu SP, Veit K, Sadikot RT.
europepmc   +1 more source

A New Phosphodiesterase Forming Nucleoside 5'-Monophosphate from Rat Liver

, 1967
Masamitsu Futai, Den’ichi Mizuno
openalex   +1 more source

The effect of topical and intraurethral alprostadil on erectile function: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Erectile dysfunction (ED) affects up to 50% of men over 40. While phosphodiesterase‐5 inhibitors (PDE5i) are the first line of medical treatment, they are not always effective. Alprostadil, available in injectable, topical, and intraurethral forms, offers an alternative treatment modality.
Iason Papadopoulos, Maksim Tishukov, Ioannis Sokolakis, Ioannis Katafigiotis, Ioannis Leotsakos, Markos Karavitakis, Julian Marcon, Christian G Stief, Nikolaos Pyrgidis   +8 more
wiley   +1 more source

A novel therapeutic approach for granuloma annulare: roflumilast 0.3% cream. [PDF]

Int J Womens Dermatol
Jenkins H, Silva V, Yelich A, Moon S.
europepmc   +1 more source

Mode of Action of Rat Liver Phosphodiesterase on a Polymer of Phosphoribosyl Adenosine Monophosphate and Related Compounds

, 1968
Masamitsu Futai, Den’ichi Mizuno, Takashi Sügimura   +2 more
openalex   +1 more source

Tritium sequence analysis of oligoribonucleotides: a combination of post-labeling and thin-layer chromatographic techniques for the analysis of partial snake venom phosphodiesterase digests [PDF]

, 1974
M. Sivarajan, Ramesh C. Gupta, Li-Li S.Y. Chia, Erika Randerath, Kurt Randerath   +4 more
openalex   +1 more source