Efficacy and Mechanism of a Glycoside Compound Inhibiting Abnormal Prion Protein Formation in Prion-Infected Cells: Implications of Interferon and Phosphodiesterase 4D-Interacting Protein [PDF]
, 2014 Keiko Nishizawa +5 more
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New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa
JEADV Clinical Practice, EarlyView.ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender +2 more
wiley +1 more source
Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors. [PDF]
, 1982 We have measured the levels of 3',5'-guanosine monophosphate (cyclic GMP) in isolated retinas from toad to investigate their correlation to the opening and closing of the light-dependent permeability of photoreceptors. When Ca2+-induced changes in cyclic
Fain, GL, Woodruff, ML
core
Induction of Specific Phosphodiesterase Isoforms by Constitutive Activation of the cAMP Pathway in Autonomous Thyroid Adenomas1 [PDF]
, 2000 Luca Persani +7 more
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Role of phosphodiesterase isoenzymes in regulating intracellular cyclic AMP in adenosine-stimulated smooth muscle cells [PDF]
, 1995 Youling L. Xiong +2 more
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Medicine Bulletin, EarlyView.This study elucidates the nephrotoxic mechanism of acetyl tributyl citrate (ATBC) by integrating network toxicology, machine learning, and single‑cell multi‑omics analysis to systematically decipher the molecular mechanisms and cell‑type‑specific regulatory networks underlying ATBC‑induced kidney injury. First, a protein‑protein interaction network was
Yimao Wu +5 more
wiley +1 more source
P1‐426: BENEFICIAL EFFECTS OF PHOSPHODIESTERASE 4 INHIBITORS ON HYPERTENSION‐INDUCED DEFECTS IN MEMORY FUNCTION IN RATS [PDF]
, 2014 Sugin Lal Jabaris S +6 more
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Post Activation Potentiation Is Greater in Human Triceps Brachii Versus Triceps Surae Muscles
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims Voluntary muscle contractions result in a temporary increase in twitch force, a phenomenon termed post activation potentiation (PAP). In rodents and other species, PAP is observed predominantly or exclusively in fast twitch muscles. However, it has been suggested that in humans, PAP occurs more or less independently of muscle
William S. Zoughaib +4 more
wiley +1 more source
Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility. [PDF]
, 1987 Ronald E. Weishaar +3 more
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Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas +3 more
wiley +1 more source