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Tyrosyl‐DNA Phosphodiesterase (Tdp1) (3′‐Phosphotyrosyl DNA Phosphodiesterase)
2006Tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes 3'-phosphotyrosyl bonds in vitro. Because topoisomerase I, a type IB topoisomerase, is the only enzyme known to form 3'-phosphotyrosine bonds in eukaryotic cells, it was proposed that Tdp1 is involved in the repair of dead-end topoisomerase I-DNA covalent complexes that may form in vivo.
Amy C, Raymond, Alex B, Burgin
openaire +2 more sources
Clinical Implication of Phosphodiesterase-4-Inhibition
International Journal of Molecular Sciences, 2022Martin Alexander Schick +2 more
exaly
Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy
Circulation, 2012Elisa Giannetta +2 more
exaly

