Results 211 to 220 of about 161,329 (309)

[Systemic sclerosis : A disease with multiple faces]. [PDF]

Dermatologie (Heidelb)
Evers C, Distler J, Distler O.
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl^- currents in the early distal convoluted tubule of the mouse kidney. [PDF]

J Biol Chem
Hu L, Zhang H, Xiao A, Qiu H, Meng X, You Y, Wang M.   +6 more
europepmc   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia-Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset. [PDF]

Muscles
Charles AL, Tetsi L, Quiring G, Barnig C, Giannini M, Meyer A, Lejay A, Lugnier C, Geny B.   +8 more
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Contractile Effects of Glucagon in Mouse Cardiac Preparations. [PDF]

Int J Mol Sci
Neumann J, Schmidt F, Braekow P, Kirchhefer U, Klimas J, Hadova K, Gergs U.   +6 more
europepmc   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková, Blanka Holendová, Jurij Dolenšek, Monika Křivonosková, Andraž Stožer, Lydie Plecitá‐Hlavatá   +5 more
wiley   +1 more source

Salvage robotic-assisted radical prostatectomy after targeted high-intensity focused ultrasound: a single-center study on feasibility, oncological and functional outcomes. [PDF]

Front Oncol
Cella L, Fasulo V, Moretto S, Beatrici E, Piccolini A, Avolio PP, Maffei D, Contieri R, Tallari A, Mallia V, Uleri A, Saita A, Hurle R, Casale P, Lazzeri M, Paciotti M, Buffi NM, Lughezzani G.   +17 more
europepmc   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source