Results 241 to 250 of about 216,066 (333)

PVRI‐GoDeep—A Global Meta‐Registry at the Crossroads of Heart and Lung

open access: yesComprehensive Physiology, Volume 16, Issue 2, April 2026.
PVRI GoDeep is a global meta‐registry that harmonizes high‐quality patient‐level data from pulmonary hypertension registries worldwide. With over 45,000 enrolees already included, it enables robust phenotyping, international comparisons, and clinically relevant research across all PH subgroups beyond the scope of single‐center or national datasets ...
Meike T. Fuenderich   +83 more
wiley   +1 more source

Anti‐Biofilm Properties of Polyurethane Biomaterials Tethered With Small Molecules via Polyethylene Glycol Linker

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 4, April 2026.
Interfering with nucleotide signaling pathways using small molecules represents a promising strategy to disrupt biofilm formation on biomaterial surfaces. This study reported a new approach for tethering small molecules onto polyurethane surfaces using a PEG long linker.
Jiale Liu   +7 more
wiley   +1 more source

Clinical Effectiveness of Rikkunshito in Neonates With Radiologically Confirmed Gastroesophageal Reflux Disease and Gastric Volvulus

open access: yesTraditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
This retrospective study demonstrates the therapeutic efficacy of Rikkunshito in neonates with radiologically confirmed gastric volvulus or gastroesophageal reflux disease. Rikkunshito treatment significantly improved weight gain and vomiting frequency without serious adverse events, suggesting it is a safe and effective pharmacologic option.
Toshihiro Nakayama   +7 more
wiley   +1 more source

Differential Gene Expression in Human Hippocampus With Aging

open access: yesAging Cell, Volume 25, Issue 4, April 2026.
2 complementary analysis from a transcriptome study in human hippocampal samples of different ages revealed a set of genes differentially expressed in aged individuals linked to inflammation and immune system pathways, DNA repair (RAD23) or neural activity.
Ander Saenz‐Antoñanzas   +9 more
wiley   +1 more source

Combined therapy with dutasteride and tadalafil vs dutasteride or tadalafil monotherapy in benign prostatic hyperplasia: a randomised phase III trial

open access: yesBJU International, Volume 137, Issue 4, Page 698-707, April 2026.
Objectives To evaluate the efficacy and safety of a fixed‐dose combination (FDC) of dutasteride and tadalafil vs monotherapy in patients with benign prostatic hyperplasia (BPH). Patients and Methods This phase III trial enrolled 667 patients. After screening and washout, eligible patients were stratified by the baseline International Prostate Symptom ...
Seung Wook Lee   +20 more
wiley   +1 more source

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