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Phosphodiesterase in Psoriasis [PDF]
British Journal of Dermatology, 1969 SUMMARY. . Phosphodiesterase activity was determined by a fluorometric method using thymidine-5′-3–0-methoxy fluorescein phosphate as a substrate, in blood serum, finger-blood, normal skin, foreskin and psoriatic skin. Higher enzyme activity was found in psoriasis both in blood-serum and finger-blood in comparison with normal controls ...
F. Zaeuba +2 more
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Electrophysiology of phosphodiesterase inhibitors
The American Journal of Cardiology, 1989Phosphodiesterase inhibitors appear to uniformly enhance atrioventricular node conduction, although milrinone seems to have the least effect. Except for digoxin, this effect on atrioventricular node conduction is similar to that noted with other inotropic agents.
Richard A. Goldstein +1 more
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Phosphodiesterase inhibitors and the eye
Clinical & Experimental Ophthalmology, 2009AbstractPhosphodiesterase type 5 (PDE5) inhibitors are effective oral treatments for erectile dysfunction and have become one of the most widely prescribed medications worldwide. The mechanism of action is to reduce the degradation of cyclic GMP (cGMP) potentiating the effect of nitric oxide in the corpus cavernosum and allowing erectile function to ...
Nathan M. Kerr, Helen V. Danesh-Meyer
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2003
Publisher Summary This chapter gives an overview on cyclic GMP-specific cGMP-binding phosphodiesterase (PDE5), a class I mammalian PDE with a catalytic site that specifically hydrolyzes the phosphodiester bond of cGMP and an allosteric site that binds cGMP with high specificity.
Sharron H. Francis, Jackie D. Corbin
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Publisher Summary This chapter gives an overview on cyclic GMP-specific cGMP-binding phosphodiesterase (PDE5), a class I mammalian PDE with a catalytic site that specifically hydrolyzes the phosphodiester bond of cGMP and an allosteric site that binds cGMP with high specificity.
Sharron H. Francis, Jackie D. Corbin
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Lung Phosphodiesterase Isoenzymes
1993The distinct phosphodiesterase isoenzyme activities in guinea-pig lung were identified and characterised. We demonstrate that protein kinase A catalyses the activation of lung Type V cyclic GMP phosphodiesterase. This occurs via a marked change in the Vmax for cyclic GMP hydrolysis.
Pyne, N J, Burns, F
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