Results 261 to 270 of about 216,066 (333)

Human Intestinal Microbiota Composition Shapes Model Polyfluoroalkyl Substance Biotransformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Differences in the human gut microbiome impact the rate and pathway of biotransformation for 6:2 polyfluoroalkyl phosphate diester (diPAP), a model polyfluoroalkyl substance. Metabolic analysis is coupled to 16S RNA analysis to identify correlations between microbial taxa abundance and PAP transformation products not previously established from ...
Sierra T. Peskett, Daniel S. Grégoire, Amy A. Rand   +2 more
wiley   +1 more source

Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Pan J, Yu M, Zhang L, Yin J, Liu J, Zhang S, Zhang P, Fan Q, Liu J, Li X.   +9 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, Volume 16, Issue 3, Page 474-486, March 2026.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The Molecular Mechanism of PDE1 Regulation. [PDF]

Cells
Nielsen J, Langgård M, Tengberg JF, Kehler J.   +3 more
europepmc   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

A bacterial nutrition strategy for plant disease control. [PDF]

Science
Wang S, Zhu L, Tian M, Wu W, Hu X, Li X, Wang J, Zhu Y, Xu J, Mou B, Yang J, Cui F, Li D, Cheng J, Liu Z, Wang MA, Qi L, Jin W, Luo ZQ, Zhou P, Lee YH, Staskawicz B, He SY, Sun W.   +23 more
europepmc   +1 more source

Trends in Inhibitors, Structural Modifications, and Structure-Function Relationships of Phosphodiesterase 4: A Review. [PDF]

Biomolecules
Sánchez-Belmonte A, Matencio A, Conesa I, Vidal-Sánchez FJ, Trotta F, López-Nicolás JM.   +5 more
europepmc   +1 more source

Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism. [PDF]

J Neurochem
d'Anglemont de Tassigny X, Jiménez-Medina A, López-López I, López-Barneo J.   +3 more
europepmc   +1 more source

Pulmonary Arterial Hypertension: Recognition and Management in Primary and Acute Care Settings. [PDF]

Cureus
Ahern BJ, Fulford ST, Long D, Miller CL.
europepmc   +1 more source