Results 71 to 80 of about 2,974,682 (398)

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

Annals of Clinical and Translational Neurology, 2014
Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction.
Takakuni Maki, Y. Okamoto, R. Carare, Y. Hase, Yorito Hattori, C. Hawkes, S. Saito, Yumi Yamamoto, Y. Terasaki, H. Ishibashi-Ueda, Akihiko Taguchi, R. Takahashi, T. Miyakawa, Raj N Kalaria, E. Lo, K. Arai, Masafumi Ihara   +16 more
semanticscholar   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Role of phosphodiesterase in glucagon resistance of large adipocytes

Journal of Lipid Research, 1974
The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter ≃ 45 μm) and large (mean diameter ≃ 78 μm ...
Richard A. De Santis, Tessa Gorenstein, James N. Livingston, Dean H. Lockwood   +3 more
doaj   +1 more source

Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors

Brazilian Journal of Pharmaceutical Sciences, 2020
Phosphodiesterases (PDE) are group of enzymes which catalyze the hydrolysis of cAMP and cGMP. Since these cyclic phosphate moieties worked as intracellular second messengers in numerous physiological processes, their inhibition can affect normal ...
Shumaila Tasneem, Muhammad Saleem, Sheikh Arshad Saeed   +2 more
doaj   +1 more source

Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent

Journal of Medicinal Chemistry, 2014
Phosphodiesterase 9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of diabetes and Alzheimer’s disease. Here we report a potent PDE9 inhibitor 3r that has an IC50 of 0.6 nM and >150-fold selectivity over other PDEs. The HepG2
Yong-Xian Shao, Manna Huang, W. Cui, Ling-Jun Feng, Yinuo Wu, Yinghong Cai, Zhe Li, Xinhai Zhu, Peiqing Liu, Y. Wan, H. Ke, Hai-bin Luo   +11 more
semanticscholar   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]

, 2012
The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma, Barthelmes, Danny Huylebroeck, Davies, Davies, El-Khamisy, El-Khamisy, El-Khamisy, El-Khamisy, Esguerra, Giovanella, Hirano, Hudson, Interthal, Interthal, Junko Murai, Katyal, Keith W. Caldecott, Ledesma, Liesbeth Vermeire, Lieve Umans, Limei Ju, Murai, Nitiss, Pommier, Pommier, Pype, Sherif F. El-Khamisy, Shunichi Takeda, Takashima, Varady, Vilotti, Yang, Yves Pommier, Zeng, Zhihong Zeng, Zhou   +36 more
core   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

RESOLUTION OF THE COUNCIL OF EXPERTS ON «THE PLACE OF PHOSPHODIESTERASE-4 INHIBITOR IN THE COMBINATION TREATMENT OF MODERATE TO SEVERE PSORIASIS AND ACTIVE PSORIATIC ARTHRITIS»

Научно-практическая ревматология, 2017
Resolution of the Council of Experts on «The place of phosphodiesterase-4 inhibitor in the combination treatment of moderate to severe psoriasis and active psoriatic arthritis».

doaj   +2 more sources

New in treatment of hyperactive bladder with urge urinary incontinence in women

Бюллетень сибирской медицины, 2012
The combination of α1 adrenoceptor blocking agent and phosphodiesterase  inhibitor of 5th type is efficient in treatment of women with hyperactive bladder and urge urinary incontinence, which was proved by the studies of urodynamic and microcirculation ...
A. I. Neimark, M. V. Razdorskaya, I. V. Snegiryov   +2 more
doaj   +1 more source