Results 251 to 260 of about 87,967 (330)

The long‐term outcome and changes in tricuspid regurgitation pressure gradient in dogs diagnosed with pulmonary hypertension and Angiostrongylus vasorum infestation

Journal of Small Animal Practice, EarlyView.
Objectives Angiostrongylus vasorum (AV) is a metastrongylid parasite that has been associated with pulmonary hypertension (PH) in dogs. The objectives of the study were to describe the clinical presentation of dogs with AV and PH, document changes in tricuspid regurgitation maximum pressure gradient (TR Max PG) in subsequent months and years, record ...
R. Turner, D. Connolly, D. Brodbelt, S. Cortellini   +3 more
wiley   +1 more source

Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia. [PDF]

Cochrane Database Syst Rev, 2018
Pattanaik S, Mavuduru RS, Panda A, Mathew JL, Agarwal MM, Hwang EC, Lyon JA, Singh SK, Mandal AK.   +8 more
europepmc   +1 more source

Inspiratory Muscle Training on Exercise Capacity, Dyspnoea and Health Status in Pulmonary Hypertension: A Randomised Controlled Trial

Respirology, EarlyView.
ABSTRACT Background and Objective To evaluate the effects of a high‐intensity inspiratory muscle training on respiratory muscle strength, exercise capacity, dyspnoea, and health‐related quality of life (HRQL) in patients with pulmonary hypertension (PH). Methods Single‐blinded, randomised controlled trial 35 women with clinically stable PH (subgroups 1
Fabrício Farias da Fontoura, Gabriela Roncato, Gisela Martina Bohns Meyer, Cássia da Luz Goulart, Fernanda Brum Spilimbergo, Gerson Cipriano Junior, Marilia Gabriela Bernadeli, Katya Rigatto, Danilo Cortozi Berton   +8 more
wiley   +1 more source

Fetal sex and the relative reactivity of human umbilical vein and arteries are key determinants in potential beneficial effects of phosphodiesterase inhibitors.

J Appl Physiol (1985)
Peyter AC, Beaumann M, Delhaes F, Joye S, Menétrey S, Baud D, Tolsa JF.   +6 more
europepmc   +1 more source

Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair. [PDF]

Int J Mol Sci, 2017
Knott EP, Assi M, Rao SN, Ghosh M, Pearse DD.   +4 more
europepmc   +1 more source

Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation

Experimental Physiology, EarlyView.
Abstract Total sleep deprivation (TSD) alters local cold tolerance and could thus increase the risk of cold injury. We evaluated the impact of acute caffeine intake, the main countermeasure to TSD‐related deleterious effects, on local cold tolerance before and after TSD.
Baptiste de Lorgeril, Pierre‐Emmanuel Tardo‐Dino, Cyprien Bourrilhon, Michael Quiquempoix, Catherine Drogou, Lise Mateo, Mégane Erblang, Philippe Colin, Pascal Van Beers, Mounir Chennaoui, Danielle Gomez‐Merino, Fabien Sauvet   +11 more
wiley   +1 more source

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

Experimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber, Kiana M. Schulze, Andrew G. Horn, Tyler E. McCoach, Zachary J. White, K. Sue Hageman, Stephanie E. Hall, Peter Sandner, Brad J. Behnke, Timothy I. Musch, David C. Poole   +10 more
wiley   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Effects of a non-xanthine adenosine antagonist. CGS 15943, and a phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice

, 1995
Masahiro Imaizumt, Shuichi Miyazaki, Haruhiko Machida, Kenji Onodera   +3 more
openalex   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source