Results 291 to 300 of about 87,967 (330)

Electrophysiology of phosphodiesterase inhibitors

The American Journal of Cardiology, 1989
Phosphodiesterase inhibitors appear to uniformly enhance atrioventricular node conduction, although milrinone seems to have the least effect. Except for digoxin, this effect on atrioventricular node conduction is similar to that noted with other inotropic agents.
Richard A. Goldstein   +1 more
openaire   +3 more sources

Phosphodiesterase inhibitors and the eye

Clinical & Experimental Ophthalmology, 2009
AbstractPhosphodiesterase type 5 (PDE5) inhibitors are effective oral treatments for erectile dysfunction and have become one of the most widely prescribed medications worldwide. The mechanism of action is to reduce the degradation of cyclic GMP (cGMP) potentiating the effect of nitric oxide in the corpus cavernosum and allowing erectile function to ...
Nathan M. Kerr, Helen V. Danesh-Meyer
openaire   +2 more sources

Phosphodiesterase 4 inhibitors

Journal of the American Academy of Dermatology, 2018
Historically, drugs available for treating atopic dermatitis (AD) have been limited to topical corticosteroids and topical calcineurin inhibitors, with systemic immunosuppressants and phototherapy reserved for severe AD. Despite their efficacy and infrequent adverse events, phobia about the use of topical steroids and calcineurin inhibitors has limited
Rema Zebda, Amy S. Paller
openaire   +3 more sources

In Defense of Phosphodiesterase 5 Inhibitors

JAMA Ophthalmology, 2022
Not ...
Belladelli, Federico   +2 more
openaire   +3 more sources

Phosphodiesterase Inhibitors and Cerebral Vasospasm

Archives of Neurology, 1975
Experimental cerebral vasospasm was studied in cat and monkey models. In the cat, the basilar artery was exposed by a transclival approach and spasm induced by the application of blood to the vessel. In the monkey, spasm was produced by injecting blood into the subarachnoid space.
Eugene S. Flamm   +3 more
openaire   +4 more sources

Phosphodiesterase-5 Inhibitors

2013
Nitric oxide (NO) signaling plays a key role in modulating vascular tone and remodeling in the pulmonary circulation. The guanylate cyclase/cyclic guanylate monophosphate-signaling pathway primarily mediates nitric oxide signaling. This pathway is critical in normal regulation of the pulmonary vasculature, and is an important target for therapy in ...
Barbara A. Cockrill, Aaron B. Waxman
openaire   +3 more sources

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