Results 91 to 100 of about 69,283 (286)

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

Diabetic nephropathy: Treatment with phosphodiesterase type 5 inhibitors

World Journal of Diabetes, 2013
The importance of nitric oxide (NO) in vascular physiology is irrefutable; it stimulates the intracellular production of cyclic guanosine monophosphate (cGMP), initiating vascular smooth muscle relaxation. This biochemical process increases the diameter of small arteries, regulating blood flow distribution between arterioles and the microvasculature ...
openaire   +2 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Side effects reported by European consumers for medications for erectile dysfunction

Journal of Research in Pharmacy Practice, 2013
Objective: To characterise consumer adverse drug reaction (ADR) reports for phosphodiesterase type 5 (PDE5) inhibitors. Methods: We included ADR reports submitted by adults to the European ADR database (EudraVigialnce) from 2007 to 2011.
Lise Aagaard, Ebba Holme Hansen
doaj   +1 more source

Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]

, 1982
As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
core   +1 more source

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]

, 2015
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla, Fallarino, Mara, Filardi, Tiziana, Gianfrilli, Daniele, Giannetta, Elisa, Lenti, Luisa, Lenzi, Andrea, Lococo, Manuela, Mandosi, Elisabetta, Morano, Susanna, Venneri, MARY ANNA   +10 more
core   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

THE CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH THE HELP OF DISTANT ISCHEMIC AND PHARMACOLOGICAL PRECONDITIONING WITH THERMAL LOCAL ASPHYXIA OF KIDNEY

Вестник урологии, 2018
This article contains the results of research of the endothelial dysfunction arising during the modeling of thermal local asphyxia of kidney and possibilities of their correction by distant ischemic and pharmacological preconditioning.
O. I. Bratchikov, M. V. Pokrovskiy, V. V. Elagin, D. A. Kostina   +3 more
doaj   +1 more source

Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory [PDF]

, 2016
Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial ...
Abel, Ted, Baillie, George W., Bruinenberg, Vibeke M., Guercio, Leonardo A., Hansen, Rolf T., Havekes, Robbert, Houslay, Miles D., Lee, Yool, Linton, Edward, Meerlo, Peter, Neves, Susana R., Park, Alan J., Tolentino, Rosa E., Tudor, Jennifer C.   +13 more
core   +5 more sources

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source