Comparative efficacy of on-demand Sildenafil, Tadalafil and daily Tadalafil for treatment of erectile dysfunction: A 12-week randomized controlled study [PDF]
Indian Journal of PsychiatryBackground: Comparison of available first line agents for treating Erectile Dysfunction (ED) with each other regarding efficacy in Indian context remains scant.
Shevya Gagal +3 more
doaj +2 more sources
Modulating phosphodiesterase-5 activity to suppress the immunosuppressive mechanisms of myeloid-derived suppressor cells in breast cancer [PDF]
Breast Cancer ResearchPhosphodiesterase-5 (PDE5) inhibitors have been shown to have potential as an adjuvant therapy for cancer. Tadalafil is a potent and selective PDE5 inhibitor that has been shown to inhibit the aggregation of myeloid-derived suppressor cells (MDSC) within
Yingxue Guo +12 more
doaj +2 more sources
A Systematic Literature Review Exploring the Efficacy and Safety of Tadalafil and Sildenafil in Pulmonary Arterial Hypertension [PDF]
Pulmonary CirculationPulmonary Arterial Hypertension (PAH) is a rare, chronic and progressive disease affecting the heart and lungs. Endothelin receptor antagonist (ERA) + phosphodiesterase type 5 inhibitor (PDE5i) treatment is recommended for all PAH patients.
Rajan Saggar +9 more
doaj +2 more sources
Potential of tadalafil and tadalafil-cellulose nanocomposite in preventing postsurgical abdominal adhesions in a rat cecal abrasion model [PDF]
Scientific ReportsThe formation of postoperative intra-abdominal adhesions is a significant challenge in veterinary practice worldwide. Thus, several attempts have been made to identify agents that prevent the occurrence of these postsurgical adhesions.
Ahmed Abdelrahiem Sadek +4 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2022 Podocyte injury is responsible for nephrotic syndrome. Previously, we found that tadalafil, a phosphodiesterase 5 inhibitor, might have protective effects on podocytes.
Natsumi Tomita +7 more
doaj +1 more source
A comparative Study of Tadalafil versus Tadalafil combined with Alpha Lipoic Acid in the treatment of Erectile Dysfunction in Diabetic Patients [PDF]
Al-Azhar International Medical Journal, 2022 Background: Erectile dysfunction (ED) is a worldwide health issue that has an influence on men's and their spouses' quality of life. The etiology of ED may be organic, psychogenic or mixed.
Hassan Abdel-Wahab +2 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2020 Introduction Sexual dysfunction is a common complication in men with type 2 diabetes and is often refractory to treatment. This study investigated the long-term influence of the phosphodiesterase 5 inhibitor (PDE5I) tadalafil on the level of sex hormones
Akiko Itoga +5 more
doaj +1 more source
Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy
Medicina, 2019 Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow.
Hiroaki Tanaka +7 more
doaj +1 more source
Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats
Pharmaceutics, 2019 Tadalafil is a cytochrome P450 (CYP) 3A4 substrate. Because there are few data on drug-drug interactions, it is advisable to take sufficient consideration when co-administering tadalafil with CYP3A4 inducers or inhibitors.
Young-Guk Na +6 more
doaj +1 more source
BMC Urology, 2019 Background Chronic inflammation is thought to be a major causative factor for the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Tadalafil, a phosphodiesterase type 5 inhibitor (PDE5-I), which has been used for
Mikio Sugimoto +11 more
doaj +1 more source